Varzaru Vlad Bogdan, Anastasiu-Popov Diana-Maria, Eftenoiu Anca-Elena, Popescu Roxana, Vlad Daliborca Cristina, Vlad Cristian Sebastian, Moatar Aurica Elisabeta, Puscasiu Daniela, Cobec Ionut Marcel
Doctoral School, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
ANAPATMOL Research Center, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.
Cancers (Basel). 2024 Sep 1;16(17):3049. doi: 10.3390/cancers16173049.
Breast cancer is one of the most common cancers and the leading cause of cancer death in women. Less than 1% of breast cancer cases are male breast cancers. Although there has been significant progress made in the management of breast cancer, due to its rarity among men, the question of whether men and women with breast cancer have the same treatment response and survival rate still needs to be answered. The primary goal of this study is to compare survival outcomes between male and female breast cancer patients.
This cohort study represents a retrospective and anonymized data analysis of 2162 breast cancer cases (19 males and 2143 females), registered over a period of 12 years, from 1 January 2010 to 31 December 2021, in the Clinic of Obstetrics and Gynecology, Diakoneo Diak Klinikum Schwäbisch Hall, Germany.
According to the Kaplan-Meier survival analysis, the estimated overall 3-year survival rate was 91.1% for women and 88.9% for men. The log-rank test of equality of survival distributions indicated a statistically significant difference in survival times between the two groups ( = 0.009). In the subsequent age-matched Kaplan-Meier analysis, the -value was below the significance threshold ( = 0.068).
Male breast cancer is a rare disease that may show some particularities in terms of survival compared to female breast cancer.
乳腺癌是最常见的癌症之一，也是女性癌症死亡的主要原因。男性乳腺癌病例不到乳腺癌病例总数的1%。尽管在乳腺癌治疗方面已取得显著进展，但由于男性乳腺癌较为罕见，乳腺癌男性和女性患者的治疗反应及生存率是否相同这一问题仍有待解答。本研究的主要目的是比较男性和女性乳腺癌患者的生存结局。
本队列研究对2010年1月1日至2021年12月31日这12年间在德国施瓦本哈尔迪亚科内奥迪亚克临床医院妇产科登记的2162例乳腺癌病例（19例男性和2143例女性）进行回顾性匿名数据分析。
根据Kaplan-Meier生存分析，女性的估计3年总生存率为91.1%，男性为88.9%。生存分布平等性的对数秩检验表明两组之间的生存时间存在统计学显著差异（P = 0.009）。在随后的年龄匹配Kaplan-Meier分析中，P值低于显著性阈值（P = 0.068）。
男性乳腺癌是一种罕见疾病，与女性乳腺癌相比，其在生存方面可能表现出一些特殊性。
