Department of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, 70124 Bari, Italy.
Cells. 2024 Aug 30;13(17):1460. doi: 10.3390/cells13171460.
Stem and progenitor cells have been observed to contribute to regenerative processes in acute renal failure and chronic kidney disease. Recent research has delved into the intricate mechanisms by which stem and progenitor cells exert their influence on kidney diseases. Understanding how these cells integrate with the existing renal architecture and their response to injury could pave the way for innovative treatment strategies aimed at promoting kidney repair and regeneration. Overall, the role of stem and progenitor cells in kidney diseases is multifaceted, with their ability to contribute to tissue regeneration, immune modulation, and the maintenance of renal homeostasis. Here, we review the studies that we have available today about the involvement of stem and progenitor cells both in regenerative therapies and in the causes of renal diseases, as well as in natural healing mechanisms, taking into account the main kidney disorders, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, C3 glomerulopathy, focal segmental glomerulosclerosis, idiopathic membranous nephropathy, anti-glomerular basement membrane glomerulonephritis, and ANCA-associated crescentic glomerulonephritis. Moreover, based on the comprehensive data available in the framework of the specific kidney diseases on stem cells and renal progenitors, we hypothesize a possible role of adult renal progenitors in exacerbating or recovering the illness.
干细胞和祖细胞已被观察到在急性肾衰竭和慢性肾脏病的再生过程中发挥作用。最近的研究深入探讨了干细胞和祖细胞对肾脏疾病产生影响的复杂机制。了解这些细胞如何与现有肾脏结构整合以及它们对损伤的反应，可能为旨在促进肾脏修复和再生的创新治疗策略铺平道路。总的来说，干细胞和祖细胞在肾脏疾病中的作用是多方面的，它们能够促进组织再生、免疫调节和肾脏内稳态的维持。在这里，我们回顾了目前关于干细胞和祖细胞在再生疗法以及肾脏疾病的病因、自然愈合机制中的作用的研究，同时考虑了主要的肾脏疾病，如 IgA 肾病、狼疮性肾炎、糖尿病肾病、C3 肾小球病、局灶节段性肾小球硬化症、特发性膜性肾病、抗肾小球基底膜肾小球肾炎和 ANCA 相关的新月体性肾小球肾炎。此外，根据特定肾脏疾病中关于干细胞和肾祖细胞的综合数据，我们假设成人肾祖细胞可能在疾病的加重或恢复中发挥作用。
