Department of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut 1107-2020, Lebanon.
Faculty of Medical Sciences, Lebanese University, Beirut 1533, Lebanon.
Cells. 2024 Sep 9;13(17):1505. doi: 10.3390/cells13171505.
Spinal cord injury (SCI) is a serious condition accompanied by severe adverse events that affect several aspects of the patient's life, such as motor, sensory, and functional impairment. Despite its severe consequences, definitive treatment for these injuries is still missing. Therefore, researchers have focused on developing treatment strategies aimed at ensuring full recovery post-SCI. Accordingly, attention has been drawn toward cellular therapy using mesenchymal stem cells. Considering their wide availability, decreased immunogenicity, wide expansion capacity, and impressive effectiveness in many therapeutic approaches, adipose-derived stem cell (ADSC) injections in SCI cases have been investigated and showed promising results. In this review, SCI pathophysiology and ADSC transplantation benefits are discussed independently, together with SCI animal models and adipose stem cell preparation and application techniques. The mechanisms of healing in an SCI post-ADSC injection, the outcomes of this therapeutic approach, and current clinical trials are also deliberated, in addition to the challenges and future perspectives, aiming to encourage further research in this field.
脊髓损伤 (SCI) 是一种伴随严重不良事件的严重疾病，影响患者生活的多个方面，如运动、感觉和功能障碍。尽管后果严重，但这些损伤仍缺乏明确的治疗方法。因此，研究人员专注于开发旨在确保 SCI 后完全康复的治疗策略。因此，人们对使用间充质干细胞的细胞疗法给予了关注。鉴于其广泛的可用性、降低的免疫原性、广泛的扩增能力以及在许多治疗方法中的显著效果，已经对 SCI 病例中的脂肪来源干细胞 (ADSC) 注射进行了研究，并显示出有希望的结果。在这篇综述中，分别讨论了 SCI 的病理生理学和 ADSC 移植的益处，以及 SCI 动物模型以及脂肪干细胞的制备和应用技术。还讨论了 SCI 后 ADSC 注射的愈合机制、这种治疗方法的结果以及当前的临床试验，以及面临的挑战和未来展望，旨在鼓励该领域的进一步研究。
