Department of Pathophysiology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 9 Marii Curie-Skłodowskiej Street, 85-094 Bydgoszcz, Poland.
Neurological Department with Stroke Unit, Specialist Hospital, 64-920 Piła, Poland.
Int J Mol Sci. 2024 Aug 29;25(17):9352. doi: 10.3390/ijms25179352.
The hemojuvelin-hepcidin regulatory axis may play a key role in the iron metabolism both systemically and locally. There is a pressing need to evaluate this tightly regulated network of iron parameters and their potential impact on the development of ischemic stroke (IS). We aimed to assess iron metabolism biomarkers in patients after IS, evaluating changes over time and considering their clinical features. We studied 45 patients diagnosed with IS. We assessed major iron metabolism parameters, such as hepcidin, soluble hemojuvelin (sHJV), soluble transferrin receptor (sTfR), and ferritin, using immunoenzymathic methods at two time points: on admission and on the 7th day post IS. We found increased ferritin levels on the 7th day post IS compared to admission, and this was observed in the entire study group ( = 0.03) and in the subgroup treated with thrombolysis ( = 0.02). The hepcidin levels, on the other hand, showed a significant decrease on the 7th day, though this difference was only evident in the entire study group ( = 0.04). We also discovered significantly elevated sHJV levels in patients with PACI stroke compared to other stroke locations, both on admission and on the 7th day post IS ( < 0.05). Significantly higher sHJV levels were observed in patients treated with thrombolysis compared to those receiving conventional treatment, regardless of the time point ( < 0.0001 and = 0.0002, respectively). Our study revealed changes in the iron metabolism parameters during stroke. The patients with anterior cerebral infarction and those treated with thrombolysis presented significantly elevated sHJV levels.
铁调素-血红蛋白相关因子轴可能在全身和局部铁代谢中发挥关键作用。迫切需要评估铁参数的这种严格调控网络及其对缺血性脑卒中（IS）发展的潜在影响。我们旨在评估 IS 后患者的铁代谢生物标志物，评估其随时间的变化，并考虑其临床特征。我们研究了 45 名确诊为 IS 的患者。我们使用免疫酶学法在两个时间点评估了主要的铁代谢参数，如铁调素、可溶性血红蛋白相关因子（sHJV）、可溶性转铁蛋白受体（sTfR）和铁蛋白：入院时和 IS 后第 7 天。我们发现与入院时相比，IS 后第 7 天的铁蛋白水平升高，且整个研究组（=0.03）和接受溶栓治疗的亚组（=0.02）均如此。另一方面，尽管这种差异仅在整个研究组中明显（=0.04），但第 7 天的铁调素水平明显下降。我们还发现与其他卒中部位相比，PACIS 患者入院时和 IS 后第 7 天的 sHJV 水平显著升高（<0.05）。与接受常规治疗的患者相比，溶栓治疗的患者无论在哪个时间点的 sHJV 水平均显著升高（分别为<0.0001 和=0.0002）。我们的研究揭示了卒中期间铁代谢参数的变化。前脑梗死患者和接受溶栓治疗的患者的 sHJV 水平显著升高。
