Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi 530000, China.
Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing 100010, China.
Brain Res Bull. 2022 Jan;178:144-154. doi: 10.1016/j.brainresbull.2021.11.014. Epub 2021 Nov 26.
Intracerebral hemorrhage (ICH)-induced brain injury is a continuous pathological process that involves the deterioration of neurological functions, such as sensory, cognitive or motor functions. Cytotoxic byproducts of red blood cell lysis, especially free iron, appear to be a significant pathophysiologic mechanism leading to ICH-induced injury. Free iron has a crucial role in secondary brain injury after ICH. Chelating iron may attenuate iron-induced neurotoxicity and may be developed as a therapeutic candidate for ICH treatment. In this review, we focused on the potential role of iron toxicity in ICH-induced injury and iron chelation therapy in the management of ICH. It will hopefully advance our understanding of the pathogenesis of ICH and lead to new approaches for treatment.
脑出血（ICH）引起的脑损伤是一个连续的病理过程，涉及神经功能的恶化，如感觉、认知或运动功能。红细胞溶解的细胞毒性副产物，特别是游离铁，似乎是导致 ICH 引起损伤的重要病理生理机制。游离铁在 ICH 后继发性脑损伤中起关键作用。螯合铁可以减轻铁诱导的神经毒性，可能被开发为 ICH 治疗的治疗候选物。在这篇综述中，我们重点介绍了铁毒性在 ICH 引起的损伤中的潜在作用以及铁螯合疗法在 ICH 治疗中的应用。这有望加深我们对 ICH 发病机制的理解，并为治疗提供新的方法。
