Stiglick A, Kalant H
Psychopharmacology (Berl). 1985;85(4):436-9. doi: 10.1007/BF00429660.
Mature rats (starting weight at least 270 g) were treated daily with cannabis extract (daily THC dose 20 mg/kg) for 3 months. After a 1- to 4-month drug-free period, residual effects on a variety of behaviors were studied. No residual effects were found in learning of an eight-arm radial maze task, nor on a differential reinforcement of low-rate responding (DRL-20) task, nor on open field activity. On the other hand, two-way shuttle box avoidance learning was facilitated by previous cannabis treatment, since cannabis-treated rats exhibited shorter mean latencies to avoid footshock than vehicle controls. The findings indicate greater vulnerability of immature organisms (previous studies) than mature organisms (the present study) to long-term effects of chronic cannabis administration.
成年大鼠（起始体重至少270克）每天接受大麻提取物治疗（每日四氢大麻酚剂量20毫克/千克），持续3个月。在1至4个月的无药期后，研究了对各种行为的残留影响。在八臂放射状迷宫任务的学习中、在低比率反应差异强化（DRL-20）任务中以及在旷场活动中均未发现残留影响。另一方面，先前的大麻治疗促进了双向穿梭箱回避学习，因为接受大麻治疗的大鼠表现出比赋形剂对照组更短的平均逃避电击潜伏期。研究结果表明，未成熟生物体（先前的研究）比成熟生物体（本研究）更容易受到长期慢性大麻给药的影响。
