Giardini V
Psychopharmacology (Berl). 1985;86(1-2):81-3. doi: 10.1007/BF00431688.
Using in rats a Conditioned Taste Aversion (CTA) procedure, chlorpromazine was shown to possess significant US properties at the highest dose tested (8 mg/kg IP repeated four times). In contrast, haloperidol failed to exert a similar effect at a dosage (1.6 mg/kg IP X 4) at least twice as high, in terms of pharmacological activity, as the effective chlorpromazine dosage. These data suggest that the induction of neuroleptic extrapyramidal side effects and the antidopaminergic properties shared by the two drugs may not be responsible for the aversive effect of chlorpromazine. However, it cannot be excluded than haloperidol produces an aversion which is antagonized by some action of the drug not shared by chlorpromazine.
通过在大鼠中采用条件性味觉厌恶（CTA）程序，已表明氯丙嗪在测试的最高剂量（8毫克/千克腹腔注射，重复4次）下具有显著的非条件刺激（US）特性。相比之下，氟哌啶醇在剂量（1.6毫克/千克腹腔注射×4）下未能产生类似效果，就药理活性而言，该剂量至少是有效氯丙嗪剂量的两倍。这些数据表明，两种药物共有的抗精神病药物锥体外系副作用的诱导和抗多巴胺能特性可能与氯丙嗪的厌恶作用无关。然而，不能排除氟哌啶醇产生的厌恶作用被氯丙嗪不具有的药物某些作用所拮抗。
