Leviner Dror B, Schultz Itay, Friedman Tom, Leizarowitz Avishai, Orvin Katia, Itelman Edward, Bolotin Gil, Sharoni Erez
Department of Cardiothoracic Surgery, Carmel Medical Center, Haifa 3436212, Israel.
The Ruth & Baruch Rappaport Faculty of Medicine, Technion, Haifa 3525433, Israel.
J Clin Med. 2024 Aug 23;13(17):4984. doi: 10.3390/jcm13174984.
: Sex-based differences in mortality have been previously observed in patients with surgically treated infective endocarditis. We sought to evaluate the risk factors leading to this difference. : A retrospective cohort from three centers in Israel comprising 376 surgically treated patients, comparing short- and long-term mortality rates and risk factors between female and male patients. : Compared to male patients, female patients had higher rates of hypertension (62% vs. 48%), higher rates of Gram-negative infections (20% vs. 11%), and more mitral valve replacement (55% vs. 42%). Diabetes and age were the most significant predictors for mortality and did not differ between female and male patients. In-hospital mortality rates did not differ between female and male patients (29% vs. 26%), and the difference in long-term mortality was not statistically significant (46% vs. 36% = 0.088). : No statistical difference was observed in short- and long-term mortality between female and male patients, most likely due to a lack of difference in the rates of important risk factors such as diabetes and age. Mortality rates decreased in the last 10 years, and a good prognosis is observed for patients surviving the initial 30 days after surgery.
此前已观察到接受手术治疗的感染性心内膜炎患者存在基于性别的死亡率差异。我们试图评估导致这种差异的风险因素。：一项来自以色列三个中心的回顾性队列研究，纳入了376例接受手术治疗的患者，比较了女性和男性患者的短期和长期死亡率及风险因素。：与男性患者相比，女性患者高血压发生率更高（62%对48%）、革兰阴性菌感染率更高（20%对11%）以及二尖瓣置换术更多（55%对42%）。糖尿病和年龄是死亡率的最重要预测因素，在女性和男性患者之间没有差异。女性和男性患者的住院死亡率没有差异（29%对26%），长期死亡率的差异无统计学意义（46%对36%，P = 0.088）。：女性和男性患者在短期和长期死亡率方面未观察到统计学差异，很可能是由于糖尿病和年龄等重要风险因素的发生率没有差异。过去10年死亡率有所下降，术后最初30天存活的患者预后良好。
