Heart Center, Turku University Hospital and University of Turku, Turku, Finland.
Department of Infectious Diseases, Turku University Hospital and University of Turku, Turku, Finland.
PLoS One. 2021 Jul 15;16(7):e0254553. doi: 10.1371/journal.pone.0254553. eCollection 2021.
Infective endocarditis (IE) is associated with high mortality. However, data on factors associated with length of stay (LOS) in hospital due to IE are scarce. In addition, long-term mortality of more than 1 year is inadequately known. In this large population-based study we investigated age and sex differences, temporal trends, and factors affecting the LOS in patients with IE and in-hospital, 1-year, 5-year and 10-year mortality of IE. Data on patients (≥18 years of age) admitted to hospital due to IE in Finland during 2005-2014 were collected retrospectively from nationwide obligatory registries. We included 2166 patients in our study. Of the patients 67.8% were men. Women were older than men (mean age 63.3 vs. 59.5, p<0.001). The median LOS was 20.0 days in men and 18.0 in women, p = 0.015. In the youngest patients (18-39 years) the median LOS was significantly longer than in the oldest patients (≥80 years) (24.0 vs. 16.0 days, p = 0.014). In-hospital mortality was 10% with no difference between men and women. Mortality was 22.7% at 1 year whereas 5- and 10-year mortality was 37.5% and 48.5%, respectively. The 5-year and 10-year mortality was higher in women (HR 1.18, p = 0.034; HR 1.18, p = 0.021). Both in-hospital and long-term mortality increased significantly with aging and comorbidity burden. Both mortality and LOS remained stable over the study period. In conclusion, men had longer hospital stays due to IE compared to women. The 5- and 10-year mortality was higher in women. The mortality of IE or LOS did not change over time.
感染性心内膜炎（IE）与高死亡率相关。然而，关于因 IE 住院的住院时间（LOS）相关因素的数据却很少。此外，对于超过 1 年的长期死亡率了解不足。在这项大型基于人群的研究中，我们调查了年龄和性别差异、时间趋势以及影响 IE 患者 LOS 以及 IE 住院、1 年、5 年和 10 年死亡率的因素。从全国强制性登记处回顾性收集了 2005-2014 年因 IE 住院的芬兰患者（≥18 岁）的数据。我们的研究共纳入 2166 例患者。患者中 67.8%为男性。女性比男性年龄大（平均年龄 63.3 岁比 59.5 岁，p＜0.001）。男性的 LOS 中位数为 20.0 天，女性为 18.0 天，p = 0.015。在最年轻的患者（18-39 岁）中，LOS 中位数明显长于最年长的患者（≥80 岁）（24.0 天比 16.0 天，p = 0.014）。住院死亡率为 10%，男性和女性之间无差异。1 年死亡率为 22.7%，5 年和 10 年死亡率分别为 37.5%和 48.5%。女性 5 年和 10 年死亡率更高（HR 1.18，p = 0.034；HR 1.18，p = 0.021）。随着年龄的增长和合并症负担的增加，住院和长期死亡率均显著增加。在整个研究期间，死亡率和 LOS 保持稳定。总之，与女性相比，男性因 IE 住院的时间更长。女性的 5 年和 10 年死亡率更高。IE 的死亡率或 LOS 随时间没有变化。
