Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan 15588, Gyeonggi-do, Republic of Korea.
Molecules. 2024 Aug 26;29(17):4034. doi: 10.3390/molecules29174034.
Prion diseases, known as a group of fatal neurodegenerative disorders caused by prions, remain incurable despite extensive research efforts. In a recent study, crude extract from Valeton () showed promising anti-prion efficacy in in vitro and in vivo models, prompting further investigation into their active compounds. We endeavored to identify the chemical constituents of the extract and discover potential anti-prion agents. With the use of centrifugal partition chromatography (CPC), major constituents were isolated from the -hexane (HX) fraction of the extract in a single step. Spectroscopic analysis confirmed the presence of curcumenone, curcumenol, and furanodienone. Subsequent efficacy testing in a cell culture model of prion disease identified curcumenol and furanodienone as active compounds. This study underscores the potential of natural products in the search for effective treatments against prion diseases.
朊病毒疾病，又称朊病毒相关的神经退行性疾病，是一组由朊病毒引起的致命疾病，尽管进行了广泛的研究，但仍无法治愈。在最近的一项研究中，从 Valeton 中提取的粗提物在体外和体内模型中显示出有希望的抗朊病毒疗效，这促使人们进一步研究其活性化合物。我们致力于鉴定 的提取物的化学成分，并发现潜在的抗朊病毒药物。使用离心分配色谱（CPC），可以从提取物的正己烷（HX）部分一步分离出主要成分。光谱分析证实存在姜黄酮、姜黄醇和呋喃二烯酮。随后在朊病毒病的细胞培养模型中进行的功效测试表明姜黄醇和呋喃二烯酮是活性化合物。这项研究强调了天然产物在寻找治疗朊病毒疾病的有效方法方面的潜力。
