School of Pharmacy, Lanzhou University, Lanzhou, 730000, P. R. China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China.
Chem Biodivers. 2020 May;17(5):e2000067. doi: 10.1002/cbdv.202000067. Epub 2020 Apr 9.
One new bisabolane-type sesquiterpenoid, together with four known bisabolane-type sesquiterpenoid derivatives and seven phenolics, was isolated from the rhizomes of Curcuma longa. Their structures were elucidated by extensive spectroscopic (IR, HR-ESI-MS, and NMR) data analysis. The possible anti-Alzheimer's disease (AD) activities of the isolated compounds were also evaluated using Caenorhabditis elegans AD pathological model, and 1β-hydroxybisabola-2,10-dien-4-one had the highest possible anti-AD activity.
从姜黄根茎中分离得到一个新的倍半萜类化合物，以及四个已知的倍半萜类衍生物和七个酚类化合物。通过广泛的光谱（IR、HR-ESI-MS 和 NMR）数据分析阐明了它们的结构。还使用秀丽隐杆线虫 AD 病理模型评估了分离化合物的可能的抗阿尔茨海默病（AD）活性，1β-羟基倍半萜-2,10-二烯-4-酮具有最高的抗 AD 活性。
