姜黄根茎中双环倍半萜类衍生物和酚类化合物的分离、鉴定及可能的抗阿尔茨海默病活性。

Isolation, Characterization, and Possible Anti-Alzheimer's Disease Activities of Bisabolane-Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa.

机构信息

School of Pharmacy, Lanzhou University, Lanzhou, 730000, P. R. China.

State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China.

出版信息

Chem Biodivers. 2020 May;17(5):e2000067. doi: 10.1002/cbdv.202000067. Epub 2020 Apr 9.

DOI:10.1002/cbdv.202000067

PMID:32154990

Abstract

One new bisabolane-type sesquiterpenoid, together with four known bisabolane-type sesquiterpenoid derivatives and seven phenolics, was isolated from the rhizomes of Curcuma longa. Their structures were elucidated by extensive spectroscopic (IR, HR-ESI-MS, and NMR) data analysis. The possible anti-Alzheimer's disease (AD) activities of the isolated compounds were also evaluated using Caenorhabditis elegans AD pathological model, and 1β-hydroxybisabola-2,10-dien-4-one had the highest possible anti-AD activity.

摘要

从姜黄根茎中分离得到一个新的倍半萜类化合物，以及四个已知的倍半萜类衍生物和七个酚类化合物。通过广泛的光谱（IR、HR-ESI-MS 和 NMR）数据分析阐明了它们的结构。还使用秀丽隐杆线虫 AD 病理模型评估了分离化合物的可能的抗阿尔茨海默病（AD）活性，1β-羟基倍半萜-2,10-二烯-4-酮具有最高的抗 AD 活性。