Department of Agroenginieering and Quality Analysis, Faculty of Production Engineering, Wroclaw University of Economics and Business, Komandorska 118-120, 53-345 Wrocław, Poland.
Department of Food Technology and Nutrition, Faculty of Production Engineering, Wroclaw University of Economics and Business, Komandorska 118-120, 53-345 Wrocław, Poland.
Nutrients. 2024 Sep 2;16(17):2940. doi: 10.3390/nu16172940.
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder marked by the buildup of triacylglycerols (TGs) in the liver. It includes a range of conditions, from simple steatosis to more severe forms like non-alcoholic steatohepatitis (NASH), which can advance to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD's prevalence is rising globally, estimated between 10% and 50%. The disease is linked to comorbidities such as obesity, type 2 diabetes, insulin resistance, and cardiovascular diseases and currently lacks effective treatment options. Therefore, researchers are focusing on evaluating the impact of adjunctive herbal therapies in individuals with NAFLD. One herbal therapy showing positive results in animal models and clinical studies is fruits from the spp. genus. This review presents an overview of the association between consuming fruits, juices, and extracts from spp. and NAFLD. The search used the following keywords: (( OR blueberry OR bilberry OR cranberry) AND ("non-alcoholic fatty liver disease" OR "non-alcoholic steatohepatitis")). Exclusion criteria included reviews, research notes, book chapters, case studies, and grants. The review included 20 studies: 2 clinical trials and 18 studies on animals and cell lines. The findings indicate that juices and extracts from fruits and leaves have significant potential in addressing NAFLD by improving lipid and glucose metabolism and boosting antioxidant and anti-inflammatory responses. In conclusion, blueberries appear to have the potential to alleviate NAFLD, but more clinical trials are needed to confirm these benefits.
非酒精性脂肪性肝病 (NAFLD) 是一种常见的慢性肝脏疾病，其特征是肝脏中三酰甘油 (TGs) 的积累。它包括一系列病症，从单纯性脂肪变性到更严重的形式，如非酒精性脂肪性肝炎 (NASH)，后者可进展为纤维化、肝硬化和肝细胞癌。NAFLD 的全球患病率正在上升，估计在 10%到 50%之间。该疾病与肥胖、2 型糖尿病、胰岛素抵抗和心血管疾病等合并症有关，目前缺乏有效的治疗选择。因此，研究人员专注于评估辅助草药疗法对 NAFLD 患者的影响。一种在动物模型和临床研究中显示出积极结果的草药疗法是 spp. 属的果实。这篇综述介绍了食用 spp. 的果实、果汁和提取物与 NAFLD 之间的关联。搜索使用了以下关键字：((蓝莓 OR 越橘 OR 蔓越莓) AND (非酒精性脂肪性肝病 OR 非酒精性脂肪性肝炎))。排除标准包括评论、研究笔记、书籍章节、案例研究和拨款。综述包括 20 项研究：2 项临床试验和 18 项关于动物和细胞系的研究。研究结果表明， spp. 的果实和叶子的果汁和提取物通过改善脂质和葡萄糖代谢、增强抗氧化和抗炎反应，具有显著的治疗非酒精性脂肪性肝病的潜力。总之，蓝莓似乎有缓解非酒精性脂肪性肝病的潜力，但需要更多的临床试验来证实这些益处。
