Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Division of Gastroenterology & Liver Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Nutrients. 2024 Sep 8;16(17):3031. doi: 10.3390/nu16173031.
BACKGROUND/OBJECTIVES: Dietary fats have been linked to the increasing incidence of chronic diseases, including inflammatory bowel diseases (IBD), namely, Crohn's disease (CD).
This study investigated the impact of pentadecanoic acid (C15:0), a type of an odd-numbered chain saturated fatty acid, for its potential anti-inflammatory properties in different mouse models of experimental IBD using the SAMP1/YitFc (SAMP) mouse line (14- or 24-week-old), including chronic ileitis and DSS-induced colitis. To quantitively assess the effect of C:15, we tested two dosages of C:15 in selected experiments in comparison to control mice. Intestinal inflammation and intestinal permeability were used as primary outcomes.
In ileitis, C:15 supplementation showed an anti-inflammatory effect in SAMP mice (e.g., a reduction in ileitis severity vs. control < 0.0043), which was reproducible when mice were tested in the DSS model of colitis (e.g., reduced permeability vs. control < 0.0006). Of relevance, even the short-term C:15 therapy prevented colitis in mice by maintaining body weight, decreasing inflammation, preserving gut integrity, and alleviating colitis signs.
Collectively, the findings from both ileitis and colitis in SAMP mice indicate that C:15 may have therapeutic effects in the treatment of IBD (colitis in the short term). This promising effect has major translational potential for the alleviation of IBD in humans.
背景/目的：膳食脂肪与慢性疾病（包括炎症性肠病，即克罗恩病）的发病率上升有关。
本研究通过 SAMP1/YitFc（SAMP）小鼠品系（14 或 24 周龄）中的慢性回肠炎和 DSS 诱导的结肠炎，研究了奇数链饱和脂肪酸十五烷酸（C15:0）对实验性 IBD 不同小鼠模型的潜在抗炎特性的影响。为了定量评估 C:15 的作用，我们在选定的实验中测试了两种剂量的 C:15，并与对照小鼠进行了比较。肠道炎症和肠道通透性被用作主要结局。
在回肠炎中，C:15 补充在 SAMP 小鼠中表现出抗炎作用（例如，与对照组相比，回肠炎严重程度降低 <0.0043），当在 DSS 诱导的结肠炎模型中测试时，这种作用是可重现的（例如，与对照组相比，通透性降低 <0.0006）。值得注意的是，即使是短期的 C:15 治疗也能通过维持体重、减少炎症、保护肠道完整性和缓解结肠炎症状来预防小鼠的结肠炎。
综上所述，SAMP 小鼠的回肠炎和结肠炎的研究结果表明，C:15 可能对 IBD（短期结肠炎）的治疗有治疗作用。这一有前景的效果对缓解人类 IBD 具有重要的转化潜力。
