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丝网印刷电极作为低成本的乳腺癌生物标志物检测传感器。

Screen-Printed Electrodes as Low-Cost Sensors for Breast Cancer Biomarker Detection.

机构信息

College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.

Qianwan Institute, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, China.

出版信息

Sensors (Basel). 2024 Aug 31;24(17):5679. doi: 10.3390/s24175679.

DOI:10.3390/s24175679
PMID:39275589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11398123/
Abstract

This review explores the emerging role of screen-printed electrodes (SPEs) in the detection of breast cancer biomarkers. We discuss the fundamental principles and fabrication techniques of SPEs, highlighting their adaptability and cost-effectiveness. The review examines various modification strategies, including nanomaterial incorporation, polymer coatings, and biomolecule immobilization, which enhance sensor performance. We analyze the application of SPEs in detecting protein, genetic, and metabolite biomarkers associated with breast cancer, presenting recent advancements and innovative approaches. The integration of SPEs with microfluidic systems and their potential in wearable devices for continuous monitoring are explored. While emphasizing the promising aspects of SPE-based biosensors, we also address current challenges in sensitivity, specificity, and real-world applicability. The review concludes by discussing future perspectives, including the potential for early screening and therapy monitoring, and the steps required for clinical implementation. This comprehensive overview aims to stimulate further research and development in SPE-based biosensors for improved breast cancer management.

摘要

本文探讨了丝网印刷电极 (SPE) 在乳腺癌生物标志物检测中的新作用。我们讨论了 SPE 的基本原理和制造技术，强调了其适应性和成本效益。本文还分析了 SPE 在检测与乳腺癌相关的蛋白质、遗传和代谢物生物标志物中的应用，介绍了最新进展和创新方法。探讨了 SPE 与微流控系统的集成及其在可穿戴设备中用于连续监测的潜力。在强调基于 SPE 的生物传感器有前景的同时，我们还讨论了灵敏度、特异性和实际应用方面的当前挑战。本文最后讨论了未来的展望，包括早期筛查和治疗监测的潜力，以及临床实施所需的步骤。本综述旨在激发基于 SPE 的生物传感器在改善乳腺癌管理方面的进一步研究和开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11398123/018cbbb604af/sensors-24-05679-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11398123/e409ac93bf60/sensors-24-05679-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11398123/8f25708a3594/sensors-24-05679-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11398123/72efae47e7cd/sensors-24-05679-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11398123/19ec97f2416e/sensors-24-05679-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11398123/7f1fdab21c9b/sensors-24-05679-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11398123/f2833618de8e/sensors-24-05679-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11398123/0b16a06530b3/sensors-24-05679-g011.jpg
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