Rigshospitalet, Spine Unit, Department of Orthopedic Surgery, Copenhagen, Denmark.
Scottish Rite for Children, Dallas, TX, USA.
Eur Spine J. 2024 Oct;33(10):3760-3766. doi: 10.1007/s00586-024-08486-1. Epub 2024 Sep 14.
To examine if coronal deformity angular ratio (C-DAR) serves as a predictor for progression to surgical magnitude in patients with Adolescent Idiopathic Scoliosis (AIS) treated with thoracolumbar sacral orthosis (TLSO).
Patients with AIS, prescribed a full-time TLSO, Cobb angle 20-40°, Risser 0-2, who wore the brace ≥ 12.9 h and reached skeletal maturity/surgery were included retrospectively. C-DAR was defined as the Cobb angle divided by the number of vertebrae in the curve, yielding a larger value in short curves. The association between C-DAR and the risk of progression to surgical magnitude (> 45°) was assessed. Secondly, we evaluated the association between pre-treatment Cobb angle and in-brace correction on the risk of progression to > 45°.
We included 165 patients with a mean Cobb angle of 30 ± 6°. Of these, 46/165 (28%) progressed ≥ 6° and 26/165 (16%) reached surgical magnitude at the end of treatment. C-DAR was a significant predictor for risk of progression to surgical magnitude with an OR of 1.9 (CI 1.2-2.9) per unit increase in C-DAR. A threshold value of 5.15 was established and demonstrated an OR 5.9 (CI 2.1-17.9) for curve progression to a surgical magnitude. Likewise, pre-treatment Cobb angle showed a significant OR 1.3(CI 1.2-1.4) per degree increase in Cobb, whereas in-brace % correction showed OR 0.96 (CI 0.93-0.98).
C-DAR is an independent predictor for progression to a surgical magnitude in AIS patients treated with bracing. Patients with a higher C-DAR should be counseled to help set realistic expectations regarding the likelihood of curve progression despite compliance with brace wear.
探讨冠状面畸形角度比(C-DAR)是否可作为青少年特发性脊柱侧凸(AIS)患者接受胸腰骶支具(TLSO)治疗后进展至手术程度的预测指标。
回顾性纳入 AIS 患者,支具处方为全天佩戴 TLSO,Cobb 角 20-40°,Risser 征 0-2,支具佩戴时间≥12.9 小时,且达到骨骼成熟/手术年龄。C-DAR 定义为 Cobb 角除以曲线中的椎体数,短曲线的比值更大。评估 C-DAR 与进展至手术程度(>45°)的风险之间的相关性。其次,我们评估了治疗前 Cobb 角与支具内矫正对进展至>45°的风险之间的相关性。
共纳入 165 例患者,平均 Cobb 角为 30±6°。其中,46/165(28%)进展≥6°,26/165(16%)在治疗结束时达到手术程度。C-DAR 是进展至手术程度的风险的显著预测因子,C-DAR 每增加一个单位,比值比(OR)为 1.9(95%CI 1.2-2.9)。建立了 5.15 的阈值,表明 C-DAR 增加 5.9(95%CI 2.1-17.9)时,曲线进展至手术程度的比值比为 5.9。同样,治疗前 Cobb 角每增加 1°,OR 为 1.3(95%CI 1.2-1.4),而支具内矫正率的 OR 为 0.96(95%CI 0.93-0.98)。
C-DAR 是 AIS 患者接受支具治疗后进展至手术程度的独立预测因子。C-DAR 较高的患者应接受咨询,以帮助其设定切合实际的期望,了解即使遵守支具佩戴,曲线仍可能进展。