Ji J, Shu X, Li X, Sundquist K, Sundquist J, Hemminki K
Center for Family and Community Medicine, Karolinska Institute, Huddinge, Sweden.
Br J Cancer. 2009 Mar 10;100(5):829-33. doi: 10.1038/sj.bjc.6604890. Epub 2009 Jan 27.
Asthma is an increasingly common disorder, affecting 5-10% of the population. It involves a dysregulated immune function, which may predispose to subsequent cancer. We examined cancer risk among Swedish subjects who had hospital admission once or multiple times for asthma. An asthma research database was created by identifying asthma patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. A total of 140 425 patients were hospitalised for asthma during 1965-2004, of whom 7421 patients developed cancer, giving an overall standardised incidence ratio (SIR) of 1.36. A significant increase was noted for most sites, with the exception of breast and ovarian cancers and non-Hodgkin's lymphoma and myeloma. Patients with multiple hospital admissions showed a high risk, particularly for stomach (SIR 1.70) and colon (SIR 1.99) cancers. A significant decrease was noted for endometrial cancer and skin melanoma. Oesophageal and lung cancers showed high risks throughout the study period, whereas stomach cancer increased towards the end of the period. The relatively stable temporal trends suggest that the asthmatic condition rather than its medication is responsible for the observed associations.
哮喘是一种日益常见的疾病，影响着5%至10%的人口。它涉及免疫功能失调，这可能会增加患后续癌症的风险。我们研究了因哮喘曾一次或多次住院的瑞典受试者的癌症风险。通过从瑞典医院出院登记册中识别哮喘患者并将他们与癌症登记册相链接，创建了一个哮喘研究数据库。在1965年至2004年期间，共有140425名患者因哮喘住院，其中7421名患者患了癌症，总体标准化发病率（SIR）为1.36。除乳腺癌、卵巢癌、非霍奇金淋巴瘤和骨髓瘤外，大多数部位的发病率显著增加。多次住院的患者风险较高，尤其是胃癌（SIR 1.70）和结肠癌（SIR 1.99）。子宫内膜癌和皮肤黑色素瘤的发病率显著下降。在整个研究期间，食管癌和肺癌的风险较高，而胃癌在研究期末有所增加。相对稳定的时间趋势表明，是哮喘病情而非其药物治疗导致了所观察到的关联。
