School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, PR China; Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-Product Safety and Quality, Ministry of Agriculture and Rural Affairs/Key Laboratory for Agro-Product Safety Risk Evaluation (Nanjing), Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu, PR China.
Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-Product Safety and Quality, Ministry of Agriculture and Rural Affairs/Key Laboratory for Agro-Product Safety Risk Evaluation (Nanjing), Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu, PR China; Collage of Plant Protection, Nanjing Agricultural University, Nanjing 210095, PR China.
Pestic Biochem Physiol. 2024 Sep;204:106092. doi: 10.1016/j.pestbp.2024.106092. Epub 2024 Aug 18.
Rice panicle blight (RPB) caused by various Fusarium spp. is an emerging disease in the major rice-growing regions of China. Epidemics of this disease cause significant yield loss and reduce grain quality by contaminating panicles with different Fusarium toxins. However, there is currently no registered fungicide for the control of RPB in China. The 14α-demethylation inhibitor (DMI) fungicide metconazole has been shown to be effective against several Fusarium spp. that cause wheat head blight, wheat crown rot and maize ear rot. In this study, we investigated the specific activity of metconazole against six Fusarium spp. that cause RPB. Metconazole significantly inhibited mycelial growth, conidium formation, germination, germ tube elongation and major toxin production in Fusarium strains collected from major rice-growing regions in China, as well as disrupting cell membrane function by inhibiting ergosterol biosynthesis. Greenhouse experiments indicated a significant reduction in blight occurrence and toxin accumulation in rice panicles treated with metconazole. Overall, our study demonstrated the potential of metconazole for managing RPB and toxin contamination, as well as providing insight into its bioactivities and modes of action of metconazole against distinct Fusarium spp.
稻曲病（RPB）由各种镰刀菌引起，是中国主要水稻种植区的一种新兴疾病。这种疾病的流行会导致严重的产量损失，并通过污染穗部而使不同的镰刀菌毒素降低谷物质量。然而，目前中国还没有登记用于防治稻曲病的杀菌剂。14α-脱甲基抑制剂（DMI）杀菌剂咪鲜胺对引起小麦赤霉病、小麦冠腐病和玉米穗腐病的几种镰刀菌有效。在这项研究中，我们调查了咪鲜胺对引起稻曲病的六种镰刀菌的特定活性。咪鲜胺对来自中国主要水稻种植区的镰刀菌菌株的菌丝生长、分生孢子形成、萌发、芽管伸长和主要毒素产生有显著抑制作用，同时通过抑制麦角固醇生物合成来破坏细胞膜功能。温室试验表明，咪鲜胺处理可显著减少水稻穗部病害发生和毒素积累。总的来说，我们的研究表明咪鲜胺在防治稻曲病和毒素污染方面具有潜力，并深入了解了咪鲜胺对不同镰刀菌的生物活性和作用方式。
