O'Sullivan Emily A, Wallis Ryan, Mossa Federica, Bishop Cleo L
Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
NPJ Aging. 2024 Sep 14;10(1):41. doi: 10.1038/s41514-024-00168-y.
Senescence is an anti-tumour mechanism and hallmark of cancer. Loss or mutation of key senescence effectors, such as p16INK4A, are frequently observed in cancer. Intriguingly, some human tumours are both proliferative and senescent-marker positive (Sen-Mark+). Here, we explore this paradox, focusing on the prognostic consequences and the current challenges in classifying these cells. We discuss future strategies for Sen-Mark+ cell detection together with emerging opportunities to exploit senescence for cancer.
衰老作为一种抗肿瘤机制，是癌症的一个标志。关键衰老效应因子（如p16INK4A）的缺失或突变在癌症中经常被观察到。有趣的是，一些人类肿瘤既具有增殖性又呈衰老标志物阳性（Sen-Mark+）。在此，我们探讨这一矛盾现象，重点关注其预后影响以及在对这些细胞进行分类时面临的当前挑战。我们讨论了Sen-Mark+细胞检测的未来策略以及利用衰老来治疗癌症的新机遇。
