Emory Global Diabetes Research Center of Woodruff Health Sciences Center and Emory University, Atlanta, GA, USA.
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Int J Obes (Lond). 2024 Dec;48(12):1785-1792. doi: 10.1038/s41366-024-01628-x. Epub 2024 Sep 14.
To study body mass index (BMI) changes among individuals aged 18-99 years with and without SARS-CoV-2 infection.
SUBJECTS/METHODS: Using real-world data from the OneFlorida+ Clinical Research Network of the National Patient-Centered Clinical Research Network, we compared changes over time in BMI in an Exposed cohort (positive SARS-CoV-2 test between March 2020-January 2022), to a contemporary Unexposed cohort (negative SARS-CoV-2 tests), and an age/sex-matched Historical control cohort (March 2018-January 2020). BMI (kg/m) was retrieved from objective measures of height and weight in electronic health records. We used target trial approaches to estimate BMI at start of follow-up and change per 100 days of follow-up for Unexposed and Historical cohorts relative to the Exposed cohort by categories of sex, race & ethnicity, age, and hospitalization status.
The study sample consisted of 249,743 participants (19.2% Exposed, 61.5% Unexposed, 19.3% Historical cohort) of whom 62% were women, 21.5% Non-Hispanic Black, 21.4% Hispanic and 5.6% Non-Hispanic other and had an average age of 51.9 years (SD: 18.9). At start of follow-up, relative to the Unexposed cohort (mean BMI: 29.3 kg/m [95% CI: 29.1, 29.4]), the Exposed (0.07 kg/m [95% CI; 0.01, 0.12]) had higher mean BMI and Historical controls (-0.20 kg/m [95% CI; -0.25, -0.15]) had lower mean BMI. Over 100 days, BMI did not change (0 kg/m [95% CI: -0.03, 0.03]) for the Exposed cohort, decreased (-0.04 kg/m [95% CI; -0.05, -0.02]) for the Unexposed cohort and increased (0.03 kg/m [95% CI; 0.01, 0.04]) for the Historical cohort. Observed differences in BMI at start of follow-up and over 100 days were consistent between Unexposed and Exposed cohorts for most subgroups, except at start of follow-up period among Males and those 65 years or older who had lower BMI among Exposed.
In a diverse real-world cohort of adults, mean BMI of those with and without SARS-CoV2 infection varied in their trajectories. The mechanisms and implications of weight retention following SARS-CoV-2 infection remain unclear.
研究 18-99 岁有和无 SARS-CoV-2 感染个体的体重指数 (BMI) 变化。
利用来自全国患者为中心的临床研究网络的 OneFlorida+临床研究网络的真实世界数据，我们将暴露队列（2020 年 3 月至 2022 年 1 月期间 SARS-CoV-2 检测阳性）中的 BMI 随时间的变化与同期未暴露队列（SARS-CoV-2 检测阴性）和年龄/性别匹配的历史对照队列（2018 年 3 月至 2020 年 1 月）进行了比较。BMI（kg/m）是从电子健康记录中身高和体重的客观测量值中检索到的。我们使用目标试验方法，根据性别、种族和民族、年龄和住院状态，估计暴露队列、未暴露队列和历史对照队列中每 100 天随访的 BMI 起始值和随访变化。
研究样本包括 249743 名参与者（19.2%为暴露组，61.5%为未暴露组，19.3%为历史队列），其中 62%为女性，21.5%为非西班牙裔黑人，21.4%为西班牙裔，5.6%为非西班牙裔其他人群，平均年龄为 51.9 岁（标准差：18.9）。在随访开始时，与未暴露队列（平均 BMI：29.3kg/m[95%CI：29.1，29.4]）相比，暴露队列（0.07kg/m[95%CI：0.01，0.12]）的平均 BMI 更高，而历史对照队列（-0.20kg/m[95%CI：-0.25，-0.15]）的平均 BMI 更低。在 100 天内，暴露队列的 BMI 没有变化（0kg/m[95%CI：-0.03，0.03]），未暴露队列的 BMI 下降（-0.04kg/m[95%CI：-0.05，-0.02]），而历史对照队列的 BMI 增加（0.03kg/m[95%CI：0.01，0.04]）。在未暴露队列和暴露队列的大多数亚组中，随访开始时和 100 天内的 BMI 差异与未暴露队列一致，但在随访开始时，男性和 65 岁及以上的人群中，暴露组的 BMI 较低。
在一个多样化的真实世界成年人队列中，有和无 SARS-CoV-2 感染个体的 BMI 轨迹存在差异。SARS-CoV-2 感染后体重保留的机制和意义仍不清楚。
