Division of Health Research, Health Innovation One, Sir John Fisher Drive, Lancaster University, Lancaster LA1 4YW, UK.
Division of Biomedical and Life Sciences, Furness College, Lancaster University, LA1 4YG, UK.
Ageing Res Rev. 2024 Nov;101:102461. doi: 10.1016/j.arr.2024.102461. Epub 2024 Sep 14.
Cognitive frailty (CF) is the conjunction of cognitive impairment without dementia and physical frailty. While predictors of each element are well-researched, mechanisms of their co-occurrence have not been integrated, particularly in terms of relationships between social, psychological, and biological factors. This interdisciplinary scoping review set out to categorise a heterogenous multidisciplinary literature to identify potential pathways and mechanisms of CF, and research gaps. Studies were included if they used the definition of CF OR focused on conjunction of cognitive impairment and frailty (by any measure), AND excluded studies on specific disease populations, interventions, epidemiology or prediction of mortality. Searches used Web of Science, PubMed and Science Direct. Search terms included "cognitive frailty" OR (("cognitive decline" OR "cognitive impairment") AND (frail*)), with terms to elicit mechanisms, predictors, causes, pathways and risk factors. To ensure inclusion of animal and cell models, keywords such as "behavioural" or "cognitive decline" or "senescence", were added. 206 papers were included. Descriptive analysis provided high-level categorisation of determinants from social and environmental through psychological to biological. Patterns distinguishing CF from Alzheimer's disease were identified and social and psychological moderators and mediators of underlying biological and physiological changes and of trajectories of CF development were suggested as foci for further research.
认知脆弱（CF）是认知障碍但没有痴呆症和身体脆弱的结合。虽然每个元素的预测因素都得到了很好的研究，但它们同时发生的机制尚未整合，特别是在社会、心理和生物因素之间的关系方面。本跨学科范围审查旨在对异质的多学科文献进行分类，以确定 CF 的潜在途径和机制以及研究空白。如果研究使用 CF 的定义或专注于认知障碍和脆弱性的结合（通过任何措施），则纳入研究，如果研究针对特定疾病人群、干预措施、流行病学或死亡率预测，则排除研究。搜索使用了 Web of Science、PubMed 和 Science Direct。搜索词包括“认知脆弱”或（“认知衰退”或“认知障碍”和（脆弱*）），并用术语引出机制、预测因素、原因、途径和风险因素。为了确保包括动物和细胞模型，添加了诸如“行为”或“认知衰退”或“衰老”等关键字。共纳入 206 篇论文。描述性分析从社会和环境因素到心理因素再到生物因素提供了决定因素的高层次分类。确定了 CF 与阿尔茨海默病的区别，并提出了社会和心理调节因素和中介因素，以研究潜在的生物和生理变化以及 CF 发展轨迹。
