认知脆弱症的流行病学和临床意义：一个小型综述。

Epidemiological and clinical significance of cognitive frailty: A mini review.

机构信息

Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan; Medical genome center, National Center for Geriatrics and Gerontology, Obu, Japan; Department of Community Health Sciences, Kobe University, Graduate School of Health Sciences, Kobe, Japan; Japan Society for the Promotion of Science, Tokyo, Japan.

Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan; Department of Cognition and Behavior Science, Nagoya University Graduate School of Medicine, Nagoya, Japan.

出版信息

Ageing Res Rev. 2018 Jul;44:1-7. doi: 10.1016/j.arr.2018.03.002. Epub 2018 Mar 12.

DOI:10.1016/j.arr.2018.03.002

PMID:29544875

Abstract

Since the operational definition of "cognitive frailty" was first proposed in 2013 by the International Academy of Nutrition and Aging and the International Association of Gerontology and Geriatrics, several studies have been carried out using this cognitive frailty model. In this review, we examined the available clinical and epidemiological evidence for cognitive frailty. Despite its low prevalence (1.0-1.8%) in the community setting, cognitive frailty has been associated with a high risk of disability, poor quality of life, and death; while cognitive frailty appears to be associated with a high risk of dementia, there is no clear evidence for this association. Again, while the prevalence of cognitive frailty appears to have increased in the clinical setting, to date, very few studies evaluated the impact of cognitive frailty. While a new definition of cognitive frailty was proposed in 2015 to incorporate "reversible" and "potential reversible" subtypes, there is a paucity of epidemiological evidence to support this definition. In conclusion, there is no consensus on the definition of cognitive frailty for use in clinical and community settings or on which measures to be used for detecting cognitive impairment. Further study is required to formulate effective preventive strategies for disability in the elderly.

摘要

自 2013 年国际营养与衰老学会和国际老年学与老年医学协会首次提出“认知衰弱”的操作定义以来，已经使用该认知衰弱模型进行了多项研究。在这篇综述中，我们研究了认知衰弱的现有临床和流行病学证据。尽管认知衰弱在社区环境中的患病率较低（1.0-1.8%），但它与残疾、生活质量差和死亡的高风险相关；而认知衰弱似乎与痴呆症的高风险相关，但没有明确的证据支持这种关联。同样，虽然认知衰弱的患病率在临床环境中似乎有所增加，但迄今为止，很少有研究评估认知衰弱的影响。虽然 2015 年提出了新的认知衰弱定义，纳入了“可逆”和“潜在可逆”亚型，但缺乏支持这一定义的流行病学证据。总之，目前对于在临床和社区环境中使用的认知衰弱的定义以及用于检测认知障碍的措施尚未达成共识。需要进一步的研究来制定针对老年人残疾的有效预防策略。