荧光化学工具揭示 CES1 介导的药物相互作用。
Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions.
机构信息
Department of Biological Sciences, Eastern Illinois University, Charleston, IL 61920, USA.
Department of Chemistry and Biochemistry, Eastern Illinois University, Charleston, IL 61920, USA.
出版信息
Chem Commun (Camb). 2024 Oct 22;60(85):12369-12372. doi: 10.1039/d4cc03632h.
Abstract
Studying factors that cause interindividual variability of carboxylesterase 1 (CES1) activity is currently difficult due to limited methods. Here, fluorogenic tools for measuring CES1 activity are developed and demonstrated to report on these factors in living cells. These tools enable experiments that will develop a deeper understanding of CES1 metabolism.
摘要
由于方法有限，目前研究导致羧酸酯酶 1（CES1）活性个体间差异的因素具有一定难度。本研究开发了用于测量 CES1 活性的荧光工具，并证明其可用于报告活细胞中的这些因素。这些工具能够开展有助于深入了解 CES1 代谢的实验。
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