Needleman P, Wyche A, Sprecher H, Elliott W J, Evers A
Biochim Biophys Acta. 1985 Sep 11;836(2):267-73. doi: 10.1016/0005-2760(85)90075-x.
The rabbit heart contains a cytosolic enzyme which selectively incorporates polyunsaturated fatty acids into phosphatidylcholine. This unique acyltransferase is selective for fatty acids, thus far tested, that are substrates for cyclooxygenase or lipoxygenase (i.e., arachidonic, eicosapentaenoic, linoleic and dihomo-gamma-linoleic acids) or which reverse the symptoms of essential fatty acid deficiency (columbinic acid). On the other hand, palmitic, oleic, 5,8,11-eicosatrienoic (n-9, Mead acid), and docosatetraenoic acid (n-6, adrenic acid) were not incorporated in phospholipids by the cytosolic acyltransferase. No such fatty acid selectivity was exhibited by the cytosolic acyl-CoA synthetase or by the acyltransferase activities present in cardiac microsomes and mitochondria.
兔心脏含有一种胞质酶，该酶可选择性地将多不饱和脂肪酸掺入磷脂酰胆碱中。这种独特的酰基转移酶对脂肪酸具有选择性，就目前所测试的而言，这些脂肪酸是环氧合酶或脂氧合酶的底物（即花生四烯酸、二十碳五烯酸、亚油酸和二高-γ-亚麻酸），或者可逆转必需脂肪酸缺乏的症状（哥伦比亚酸）。另一方面，棕榈酸、油酸、5,8,11-二十碳三烯酸（n-9，米德酸）和二十二碳四烯酸（n-6，肾上腺酸）不会被胞质酰基转移酶掺入磷脂中。胞质酰基辅酶A合成酶或心脏微粒体和线粒体中存在的酰基转移酶活性均未表现出这种脂肪酸选择性。
