Fujimoto Y, Tsunomori M, Sumiya T, Nishida H, Sakuma S, Fujita T
Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan.
Prostaglandins Leukot Essent Fatty Acids. 1995 Apr;52(4):255-8. doi: 10.1016/0952-3278(95)90046-2.
The effects of fatty acyl coenzyme A (CoA) esters (palmitoyl-, stearoyl-, oleoyl-, linoleoyl- and arachidonoyl--CoA) on the activities of lipoxygenase and cyclooxygenase in rabbit platelets were examined. Palmitoyl-, stearoyl-, oleoyl- and linoleoyl- CoA were potent inhibitors of platelet lipoxygenase activity. In addition to the lipoxygenase, the four fatty acyl-CoA esters elicited inhibitory activity on platelet cyclooxygenase, although the inhibition was a little weaker. The CoA derivative of the icosanoid precursor arachidonic acid (AA) showed little inhibition on lipoxygenase and cyclooxygenase. Palmitic, stearic and oleic acids had little or no effect on lipoxygenase and cyclooxygenase, in contrast with their CoA derivatives. Linoleic acid was more potent than linoleoyl-CoA as an inhibitor of the cyclooxygenase, but it was a weak inhibitor of the lipoxygenase. These results suggest that the CoA derivatives of palmitic, stearic, oleic and linoleic acids have the potential to modulate both platelet lipoxygenase and cyclooxygenase activities and may have functional effects within platelets.
研究了脂肪酰辅酶A（CoA）酯（棕榈酰-CoA、硬脂酰-CoA、油酰-CoA、亚油酰-CoA和花生四烯酰-CoA）对兔血小板中脂氧合酶和环氧化酶活性的影响。棕榈酰-CoA、硬脂酰-CoA、油酰-CoA和亚油酰-CoA是血小板脂氧合酶活性的强效抑制剂。除脂氧合酶外，这四种脂肪酰-CoA酯对血小板环氧化酶也有抑制活性，不过抑制作用稍弱。二十碳类花生酸前体花生四烯酸（AA）的CoA衍生物对脂氧合酶和环氧化酶的抑制作用很小。与它们的CoA衍生物相比，棕榈酸、硬脂酸和油酸对脂氧合酶和环氧化酶几乎没有影响。亚油酸作为环氧化酶抑制剂比亚油酰-CoA更有效，但它是脂氧合酶的弱抑制剂。这些结果表明，棕榈酸、硬脂酸、油酸和亚油酸的CoA衍生物有调节血小板脂氧合酶和环氧化酶活性的潜力，可能在血小板内具有功能作用。
