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伴有融合的脐尿管炎性肌纤维母细胞瘤:1例报告及文献复习

Urachal inflammatory myofibroblastic tumor with fusion: A case report and literature review.

作者信息

Tara Nair, Mehta Shailee, Trivedi Priti P, Patel Keval, Trivedi Trupti

机构信息

Department of Oncopathology, The Gujarat Cancer and Research Institute, India.

Department of Urology, The Gujarat Cancer and Research Institute, India.

出版信息

Urol Case Rep. 2024 Aug 28;56:102844. doi: 10.1016/j.eucr.2024.102844. eCollection 2024 Sep.

Abstract

Urachal tumors are rare and comprise of both benign and malignant neoplasms. Epithelial origin tumors are more common than mesenchymal origin tumors. We report a case Urachal inflammatory myofibroblastic tumor (IMFT) in a 12 year old boy who presented with symptoms of lower abdominal pain and burning micturition. Upon evaluation was found to have a soft tissue mass anterior to urinary bladder wall. A laparoscopic excision of tumor was done. Histopathological and immunohistochemical examination confirmed the diagnosis of IMFT. Next generation sequencing identified FN1-ALK gene fusion.

摘要

脐尿管肿瘤罕见,包括良性和恶性肿瘤。上皮起源的肿瘤比间充质起源的肿瘤更常见。我们报告一例12岁男孩的脐尿管炎性肌成纤维细胞瘤(IMFT),该男孩表现为下腹痛和排尿烧灼感。经评估发现膀胱壁前方有一软组织肿块。通过腹腔镜切除了肿瘤。组织病理学和免疫组织化学检查确诊为IMFT。二代测序鉴定出FN1-ALK基因融合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbdf/11402050/f50f0e2cfc07/gr1.jpg

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