Siregar Muhammad Fg, Terauchi Masakazu, Sari Rizka A, Adella Cut A, Prabudi Muhammad O, Barus Melvin Ng, Rivany Riza, Tobing Immanuel Dl, Azmeila Selly
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, H. Adam Malik General Hospital, Medan, Indonesia.
Narra J. 2024 Aug;4(2):e745. doi: 10.52225/narra.v4i2.745. Epub 2024 May 27.
Postmenopausal women often experience hormonal changes and shifts in fat composition, affecting weight gain and obesity. Understanding the link between hormones, especially estrogen and leptin, is key to managing weight and lowering disease risk in menopausal women. The aim of this study was to compare the levels of leptin and estrone in menopausal women with normal weight and obesity. A cross-sectional study was conducted on menopausal women, either normal body mass index (BMI) or obese, at H. Adam Malik General Hospital, Medan, Indonesia. Blood samples were collected to measure leptin and estrone levels using the enzyme-linked immunosorbent assay (ELISA) method. The differences in leptin levels between groups were analyzed using the Wilcoxon test, while the correlation between BMI and leptin was examined using the Pearson correlation test. The disparity in estrone levels in both groups was analyzed using the Mann-Whitney test and the correlations between variables were assessed using the Spearman or Pearson correlation tests as appropriate. The mean leptin levels in normal BMI and obesity groups were 17.73±4.96 and 25.46±12.95 ng/mL, respectively, and were statistically different (=0.006). The mean estrone levels in menopausal women with normal BMI and obesity were 943.23±391.79 and 851.38±282.23 ng/mol, respectively and were not statistically different (=0.564). A significant positive correlation was found between BMI and leptin level (=0.59; <0.001), while BMI and estrone were not significantly correlated (=0.083; =0.559). In conclusion, leptin level was significantly different between BMI groups and had a strong positive correlation with BMI. This finding could be an important insight in body weight management and disease risk prevention in menopausal women.
绝经后女性常经历激素变化和脂肪成分改变，影响体重增加和肥胖。了解激素之间的联系，尤其是雌激素和瘦素，是控制绝经后女性体重和降低疾病风险的关键。本研究的目的是比较体重正常和肥胖的绝经后女性的瘦素和雌酮水平。在印度尼西亚棉兰市的H. Adam Malik综合医院，对体重正常或肥胖的绝经后女性进行了一项横断面研究。采集血样，采用酶联免疫吸附测定（ELISA）法测量瘦素和雌酮水平。采用Wilcoxon检验分析各组间瘦素水平的差异，采用Pearson相关检验检验BMI与瘦素之间的相关性。采用Mann-Whitney检验分析两组雌酮水平的差异，并根据情况采用Spearman或Pearson相关检验评估变量之间的相关性。体重正常组和肥胖组的平均瘦素水平分别为17.73±4.96和25.46±12.95 ng/mL，差异有统计学意义（=0.006）。体重正常和肥胖的绝经后女性的平均雌酮水平分别为943.23±391.79和851.38±282.23 ng/mol，差异无统计学意义（=0.564）。BMI与瘦素水平之间存在显著正相关（=0.59；<0.001），而BMI与雌酮之间无显著相关性（=0.083；=0.559）。总之，BMI组之间的瘦素水平存在显著差异，且与BMI呈强正相关。这一发现可能为绝经后女性的体重管理和疾病风险预防提供重要见解。
