Kumar Ratan, Mal Kheraj, Razaq Muhammad Khalid, Magsi Mansoor, Memon Muhammad Khizar, Memon Sidra, Afroz Maham Noor, Siddiqui Humza F, Rizwan Amber
Cardiology, Khairpur Medical College, Khairpur, PAK.
Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.
Cureus. 2020 Dec 19;12(12):e12178. doi: 10.7759/cureus.12178.
Introduction Leptin, a hormone released by the body to regulate energy balance by inhibiting hunger, decreases fat storage in adipocytes. Leptin is thought to play some role in obesity and insulin resistance. In this study, our aim is to see the association of leptin with obesity and insulin resistance. Methods This case-control study was conducted in a tertiary care hospital in Pakistan from January 2020 to April 2020. Ninety-two participants with BMI greater than 25 kg/m, with no known comorbidities were enrolled in the study after informed consent. Ninety-two participants, who came to the outpatient department without a history of chronic disease, with BMI less than 25 kg/m were enrolled as a control group. Data were collected via self-structured questionnaires. Their blood was drawn and sent to the laboratory for cholesterol levels, insulin resistance and leptin levels. Results Serum leptin levels (51.24 ± 18.12 vs. 9.10 ± 2.99: p-value, < 0.0001), serum cholesterol levels (198.2 ± 32.1 vs. 151.2 ± 21.2, p-value < 0.0001) and insulin resistance (7.9 ± 2.1 vs. 6.3 ± 1.9, p-value < 0.0001) were higher in obese patients. Conclusion As per the results of this study, obesity was associated with increase serum leptin levels and insulin resistance. Further multi-centric studies are required to prove the possible relationship, which might help devise plans to manage obesity.
引言
瘦素是身体释放的一种激素，通过抑制饥饿来调节能量平衡，减少脂肪细胞中的脂肪储存。瘦素被认为在肥胖和胰岛素抵抗中起一定作用。在本研究中，我们的目的是观察瘦素与肥胖和胰岛素抵抗之间的关联。
方法
本病例对照研究于2020年1月至2020年4月在巴基斯坦的一家三级护理医院进行。92名体重指数（BMI）大于25kg/m²且无已知合并症的参与者在获得知情同意后被纳入研究。92名前来门诊且无慢性病病史、BMI小于25kg/m²的参与者被纳入对照组。数据通过自行编制的问卷收集。采集他们的血液并送往实验室检测胆固醇水平、胰岛素抵抗和瘦素水平。
结果
肥胖患者的血清瘦素水平（51.24±18.12 vs. 9.10±2.99，p值<0.0001）、血清胆固醇水平（198.2±32.1 vs. 151.2±21.2，p值<0.0001）和胰岛素抵抗（7.9±2.1 vs. 6.3±1.9，p值<0.0001）更高。
结论
根据本研究结果，肥胖与血清瘦素水平升高和胰岛素抵抗有关。需要进一步的多中心研究来证实这种可能的关系，这可能有助于制定管理肥胖的计划。
