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妊娠肝内胆汁淤积症诊治历程:一份自传体病例报告

Navigating the Intrahepatic Cholestasis of Pregnancy: An Autobiographical Case Report.

作者信息

Dam Barna

机构信息

Department of Internal Medicine, Kumudini Women's Medical College, Tangail, BGD.

出版信息

Cureus. 2024 Aug 13;16(8):e66770. doi: 10.7759/cureus.66770. eCollection 2024 Aug.

DOI:10.7759/cureus.66770
PMID:39280363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11393478/
Abstract

Intrahepatic cholestasis of pregnancy (ICP) is a liver condition commonly occurring during pregnancy, with an unclear etiology. This condition not only causes significant discomfort for the mother due to severe itching but also poses serious risks to the fetus. Effective and timely management of ICP, including diagnosis, consistent monitoring, and treatment, is crucial to mitigate maternal discomfort and prevent fetal complications. The challenges in managing ICP include the absence of clear initial diagnostic criteria, delays in lab results, evolving treatment guidelines, and the financial burden of therapy. This case report shares the author's personal encounter with ICP, detailing the diagnosis, treatment pathway, impacts on the newborn, and the emotional journey during and after pregnancy. This report aims to enhance understanding and awareness of ICP, particularly among populations in the United States where the disease is less prevalent.

摘要

妊娠期肝内胆汁淤积症(ICP)是一种在孕期常见的肝脏疾病,病因不明。这种病症不仅会因严重瘙痒给母亲带来极大不适,还会给胎儿带来严重风险。对ICP进行有效且及时的管理,包括诊断、持续监测和治疗,对于减轻母亲不适以及预防胎儿并发症至关重要。管理ICP面临的挑战包括缺乏明确的初始诊断标准、实验室结果延迟、治疗指南不断变化以及治疗的经济负担。本病例报告分享了作者个人与ICP的遭遇,详细介绍了诊断、治疗过程、对新生儿的影响以及孕期和产后的情感历程。本报告旨在增进对ICP的理解和认识,尤其是在美国这种该疾病不太常见的人群中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f4/11393478/86cc3621bc47/cureus-0016-00000066770-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f4/11393478/86cc3621bc47/cureus-0016-00000066770-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f4/11393478/86cc3621bc47/cureus-0016-00000066770-i01.jpg

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本文引用的文献

1
Navigating Uncertainty: A Case Study of Intrahepatic Cholestasis of Pregnancy.驾驭不确定性:妊娠肝内胆汁淤积症病例研究
J Midwifery Womens Health. 2022 May;67(3):398-402. doi: 10.1111/jmwh.13362. Epub 2022 Apr 4.
2
Intrahepatic Cholestasis of Pregnancy: An Autobiographical Case Report.妊娠肝内胆汁淤积症:一份病例报告自述
Cureus. 2022 Jan 18;14(1):e21366. doi: 10.7759/cureus.21366. eCollection 2022 Jan.
3
Intrahepatic cholestasis of pregnancy: Association with glycaemic control in gestational diabetes.妊娠期肝内胆汁淤积症:与妊娠期糖尿病血糖控制的关联
Diabet Med. 2021 Aug;38(8):e14574. doi: 10.1111/dme.14574. Epub 2021 Apr 7.
4
Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes and preeclampsia.妊娠期肝内胆汁淤积症与妊娠期糖尿病和先兆子痫的风险增加有关。
Ann Transl Med. 2020 Dec;8(23):1574. doi: 10.21037/atm-20-4879.
5
Society for Maternal-Fetal Medicine Consult Series #53: Intrahepatic cholestasis of pregnancy: Replaces Consult #13, April 2011.母胎医学会咨询系列第 53 号:妊娠肝内胆汁淤积症:取代 2011 年 4 月的咨询 13 号。
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Cochrane Database Syst Rev. 2020 Jul 27;7(7):CD000493. doi: 10.1002/14651858.CD000493.pub3.
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Case Rep Obstet Gynecol. 2019 Dec 27;2019:4980610. doi: 10.1155/2019/4980610. eCollection 2019.
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Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study.妊娠期肝内胆汁淤积症的围产儿结局:一项 8 年的病例对照研究。
PLoS One. 2020 Feb 19;15(2):e0228213. doi: 10.1371/journal.pone.0228213. eCollection 2020.
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J Matern Fetal Neonatal Med. 2021 Nov;34(21):3614-3622. doi: 10.1080/14767058.2019.1685965. Epub 2019 Nov 19.
10
Pregnancy and bile acid disorders.妊娠与胆汁酸紊乱。
Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G1-G6. doi: 10.1152/ajpgi.00028.2017. Epub 2017 Apr 27.