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溃疡性结肠炎合并心脏代谢疾病并并发自身免疫性胰腺炎。

Ulcerative Colitis Associated with Cardiometabolic Disease and Complicated with Autoimmune Pancreatitis.

作者信息

Chiba Mitsuro, Miura Takeshi, Matsuzawa Hisanori, Tsuji Tsuyotoshi, Tozawa Haruhiko, Zeniya Akira

机构信息

Division of Gastroenterology, Akita City Hospital, Akita, Japan.

Division of Diabetes and Metabolism, Akita City Hospital, Akita, Japan.

出版信息

J Lifestyle Med. 2024 Aug 31;14(2):98-102. doi: 10.15280/jlm.2024.14.2.98.

Abstract

Diet-related cardiometabolic diseases and inflammatory bowel disease, common previously in Western countries, are global problems. We hypothesized that inflammatory bowel disease is a lifestyle disease primarily mediated by the current Western diet. We report here the simultaneous onset of ulcerative colitis and autoimmune pancreatitis, a rare systemic complication of inflammatory bowel disease, 2 months after acute myocardial infarction in a patient with type 2 diabetes. A 67-year-old man with type 2 diabetes was referred to us because of newly diagnosed ulcerative colitis 2 months after acute myocardial infarction. A plant-based diet was provided during hospitalization. An abrupt deterioration in plasma glucose and hemoglobin A1c due to asymptomatic type 2 autoimmune pancreatitis was observed. Prednisolone administration under intensive insulin therapy led to the remission of both diseases. This case was an illustrative one of association between cardiometabolic diseases and inflammatory bowel diseases caused by current unhealthy diets and their shared pathogenesis.

摘要

与饮食相关的心脏代谢疾病和炎症性肠病,以前在西方国家很常见,现在是全球性问题。我们推测炎症性肠病是一种主要由当前西方饮食介导的生活方式疾病。我们在此报告一名2型糖尿病患者在急性心肌梗死后2个月同时出现溃疡性结肠炎和自身免疫性胰腺炎,后者是炎症性肠病罕见的全身性并发症。一名67岁的2型糖尿病男性因急性心肌梗死后2个月新诊断出溃疡性结肠炎而转诊至我院。住院期间提供了以植物为基础的饮食。观察到由于无症状的2型自身免疫性胰腺炎导致血浆葡萄糖和糖化血红蛋白A1c突然恶化。在强化胰岛素治疗下给予泼尼松龙导致两种疾病均缓解。该病例是当前不健康饮食导致的心脏代谢疾病和炎症性肠病之间关联及其共同发病机制的一个例证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e91/11391335/1221c8615a75/jlm-14-2-98-f1.jpg

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