Xu Tingting, Liu Chunfang, Zhang Xiulian, Geng Lin, Wang Hongwei, Li Li, Zhu Shengliang
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, China.
Evid Based Complement Alternat Med. 2022 Sep 27;2022:3957084. doi: 10.1155/2022/3957084. eCollection 2022.
The Shugan Hewei recipe (SHR) is a well-recognized traditional Chinese medicine (TCM) prescription that has been shown to significantly improve chest pain, acid regurgitation, and the mood of GERD. Nonetheless, the underlying mechanisms remain unclear. In this study, the active compounds and targets of SHR were predicted using network pharmacology. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were utilized to explore the therapeutic mechanism of SHR. Combined with the drug target obtained from network pharmacology, the therapeutic effect and mechanism of SHR were observed. SHR's main active compounds included quercetin, kaempferol, and luteolin. The core targets of SHR and GERD were TGF-1, IL-1, IL-4, CXCL10, MAPK1, MAPK3, CXCL8, IL-10, IL-2, and FOS, involving virus infection, inflammatory response, and body immunity. The core targets of SHR during the treatment of mental disorders were GABR, GABR, GABR, GABR, and GABR, involving synaptic transmission and transmembrane movement. Animal experiments revealed that SHR could repair the lower esophageal mucosa, mediate inflammatory factors, and GABA receptors and improve the behavior of rats. Overall, our results substantiate that SHR has huge prospects for widespread application in treating GERD subjects with anxiety and depression.
疏肝和胃方（SHR）是一种公认的中药方剂，已被证明能显著改善胃食管反流病（GERD）患者的胸痛、反酸及情绪。然而，其潜在机制仍不清楚。在本研究中，运用网络药理学预测了SHR的活性成分和靶点。利用基因本体（GO）和京都基因与基因组百科全书（KEGG）分析来探究SHR的治疗机制。结合从网络药理学获得的药物靶点，观察了SHR的治疗效果和机制。SHR的主要活性成分包括槲皮素、山奈酚和木犀草素。SHR和GERD的核心靶点有转化生长因子-1、白细胞介素-1、白细胞介素-4、CXC趋化因子配体10、丝裂原活化蛋白激酶1、丝裂原活化蛋白激酶3、CXC趋化因子配体8、白细胞介素-10、白细胞介素-2和FOS，涉及病毒感染、炎症反应和机体免疫。SHR在治疗精神障碍时的核心靶点是GABR、GABR、GABR、GABR和GABR，涉及突触传递和跨膜运动。动物实验表明，SHR可修复食管下段黏膜，调节炎症因子、GABA受体，并改善大鼠行为。总体而言，我们的结果证实SHR在治疗伴有焦虑和抑郁的GERD患者方面具有广泛应用的巨大前景。
