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经皮经肝乳头球囊扩张及取石术治疗胆总管结石:单中心经验

Percutaneous transhepatic papillary ballooning and extraction for common bile duct stones: a single-center experience.

作者信息

Hou Rongna, Zhang Chengzhi, Song Mengyao, Sun Zhanguo, Fang Yi, Han Xinwei, Jiao Dechao

机构信息

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

出版信息

Quant Imaging Med Surg. 2024 Sep 1;14(9):6613-6620. doi: 10.21037/qims-24-325. Epub 2024 Aug 12.

Abstract

BACKGROUND

At present, some common bile duct stones (CBDSs) cannot be removed by conventional endoscopic treatment. Percutaneous transhepatic papillary ballooning and extraction (PTPBE) is a promising treatment for CBDSs. This study aimed to evaluate the feasibility and efficacy of PTPBE for removing CBDSs.

METHODS

From April 2013 to April 2021, 29 patients with CBDSs underwent PTPBE at The First Affiliated Hospital of Zhengzhou University; their clinical data were retrospectively analyzed. The technical success, clinical success, procedure time, radiation dose, 1-year CBDSs recurrence rate, and incidence of early/late complications were recorded, and white blood cell (WBC) counts and alanine aminotransferase (ALT), C-reactive protein (CRP), total bilirubin (TBIL), and carbohydrate antigen-199 (CA-199) levels were compared before the interventional procedure and 1 month later.

RESULTS

The CBDSs were successfully removed in 29 patients (the CBDSs in 20 patients were resolved once, and in 9 patients, they were resolved twice). The mean procedure time and radiation dose were 56.38±13.56 minutes and 732.07±262.23 miligray (mGy), respectively. The technical and clinical success rates were both 100%. The incidence of early complications (including pancreatitis and bile duct bleeding) and late complications (reflux cholangitis) was 10.34% and 3.45%, respectively. The WBC (both P<0.01), ALT (both P<0.01), CRP (both P<0.01), CA-199 (both P<0.01), and TBIL (both P<0.01) significantly decreased before PTPBE and 1 month later.

CONCLUSIONS

PTPBE is a safe and effective alternative solution for elderly patients who cannot undergo or refuse traditional surgical and endoscopic treatments.

摘要

背景

目前,一些胆总管结石(CBDS)无法通过传统内镜治疗取出。经皮经肝胆总管乳头球囊扩张及取石术(PTPBE)是一种有前景的治疗CBDS的方法。本研究旨在评估PTPBE治疗CBDS的可行性和疗效。

方法

2013年4月至2021年4月,29例CBDS患者在郑州大学第一附属医院接受了PTPBE;对其临床资料进行回顾性分析。记录技术成功率、临床成功率、手术时间、辐射剂量、1年CBDS复发率以及早期/晚期并发症的发生率,并比较介入手术前和术后1个月的白细胞(WBC)计数、丙氨酸氨基转移酶(ALT)、C反应蛋白(CRP)、总胆红素(TBIL)和糖类抗原199(CA-199)水平。

结果

29例患者的CBDS均成功取出(20例患者的CBDS一次取出,9例患者的CBDS两次取出)。平均手术时间和辐射剂量分别为56.38±13.56分钟和732.07±262.23毫戈瑞(mGy)。技术成功率和临床成功率均为100%。早期并发症(包括胰腺炎和胆管出血)和晚期并发症(反流性胆管炎)的发生率分别为10.34%和3.45%。PTPBE前和术后1个月,WBC(P均<0.01)、ALT(P均<0.01)、CRP(P均<0.01)、CA-199(P均<0.01)和TBIL(P均<0.01)均显著下降。

结论

对于无法接受或拒绝传统手术和内镜治疗的老年患者,PTPBE是一种安全有效的替代解决方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a85b/11400688/c302c9c17576/qims-14-09-6613-f1.jpg

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