Song Danni, Jiang Weiwei, Hu Shuang, Zhu Rong, Pu Congshan, Wang Yiting, Shan Chunjian, Zhao Chun
Department of Obstetrics, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, 210004, People's Republic of China.
Reproductive Center, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, 210004, People's Republic of China.
Int J Womens Health. 2024 Sep 11;16:1493-1504. doi: 10.2147/IJWH.S468644. eCollection 2024.
There are multiple psychological symptoms in women undergoing assisted reproductive technology, which seriously affect health-related quality of life and even cause patients to stop treatment.
This study aimed to identify psychological symptom clusters and their influencing factors in women undergoing assisted reproductive technology.
A cross-sectional survey was conducted from June to November 2023 at the reproductive centers of Nanjing Women and Children's Healthcare Hospital. Data on demographic and clinical characteristics and Symptom Checklist-90 were collected. Exploratory factor analysis was performed to identify psychological symptom clusters. Univariate logistic regression analysis and multivariate logistic regression analysis were performed to explore influencing factors.
A total of 213 patients were recruited. The study found that the included participants scored higher on all SCL scales than the general Chinese females. The three most common were trouble remembering things (81.7%), feeling easily annoyed or irritated (81.2%), and feeling low in energy or slowed down (70.9%). Six symptom clusters were identified: paranoid ideation, depression, obsessive-compulsive disorder, interpersonal sensitivity, somatization, and sleep disorders. Multivariate logistic regression analysis showed that duration of infertility treatment (>12 months) was identified as a risk factor for sleep disorder cluster (=2.833, 95% CI:1.3555.922), adverse pregnancy history was identified as a risk factor for paranoid ideation cluster (=2.961,95% CI:1.4066.253), depression cluster (=2.404,95% CI:1.2404.660), and obsessive-compulsive cluster (=1.810, 95% CI:1.0163.233), financial burden during treatment was identified as risk factors for all symptom clusters[(=5.869, 95% CI:1.71720.057),(=6.490,95% CI:2.21019.063),(=3.034,95% CI:1.5605.898),(=7.078,95% CI:2.42020.698),(=4.532,95% CI:1.84510.397),(=2.151,95% CI:1.1294.098)].
Women undergoing ART experience various psychological symptoms that are interrelated and exist in the form of symptom clusters. More attention should be paid to the psychological status of patients with longer duration of infertility treatment, adverse pregnancy history, and financial burden during treatment. This study guides the development of targeted and effective psychological interventions to facilitate symptom management in women undergoing ART.
接受辅助生殖技术的女性存在多种心理症状，严重影响健康相关生活质量，甚至导致患者停止治疗。
本研究旨在识别接受辅助生殖技术的女性的心理症状群及其影响因素。
2023年6月至11月在南京市妇幼保健院生殖中心进行横断面调查。收集人口统计学和临床特征数据以及症状自评量表90（SCL-90）。进行探索性因素分析以识别心理症状群。进行单因素逻辑回归分析和多因素逻辑回归分析以探索影响因素。
共招募213例患者。研究发现，纳入的参与者在所有SCL量表上的得分均高于中国普通女性。最常见的三种症状是记忆力减退（81.7%）、容易烦恼或激怒（81.2%）以及精力不足或行动迟缓（70.9%）。识别出六个症状群：偏执观念、抑郁、强迫症、人际敏感、躯体化和睡眠障碍。多因素逻辑回归分析显示，不孕治疗时间（>12个月）被确定为睡眠障碍群的危险因素（β=2.833，95%CI：1.3555.922），不良孕史被确定为偏执观念群（β=2.961，95%CI：1.4066.253）、抑郁群（β=2.404，95%CI：1.2404.660）和强迫症状群（β=1.810，95%CI：1.0163.233）的危险因素，治疗期间的经济负担被确定为所有症状群的危险因素[（β=5.869，95%CI：1.71720.057），（β=6.490，95%CI：2.21019.063），（β=3.034，95%CI：1.5605.898），（β=7.078，95%CI：2.42020.698），（β=4.532，95%CI：1.84510.397），（β=2.151，95%CI：1.1294.098）]。
接受辅助生殖技术的女性经历各种相互关联的心理症状，并以症状群的形式存在。应更加关注不孕治疗时间较长、有不良孕史以及治疗期间有经济负担的患者的心理状态。本研究指导制定有针对性的有效心理干预措施，以促进接受辅助生殖技术女性的症状管理。
