一项关于皮肤黑色素瘤和晒伤遗传易感性的孟德尔随机化研究。
A Mendelian randomization study of genetic liability to cutaneous melanoma and sunburns.
作者信息
Lu Fengmin, Wang Ling, Ma Xixing, Li Yanling
机构信息
Department of Dermatology, Clinical Medical Research Center of Dermatology and Venereal Disease in Hebei Province, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
出版信息
Front Oncol. 2024 Aug 30;14:1393833. doi: 10.3389/fonc.2024.1393833. eCollection 2024.
BACKGROUND
Some studies have reported that sunburns and cutaneous melanoma (CM) risk is increasing, but a clear causal link has yet to be established.
METHODS
This current study conducted a two-sample Mendelian randomization (MR) approach to clarify the association and causality between sunburn history and CM using large-scale genome-wide association study data.
RESULTS
The inverse-variance weighted method result showed that sunburn might be associated with the risk of CM increasing (p = 2.21 × 10, OR = 1.034, 95% CI= 1.027-1.041), causally. The MR-Egger regression, weighted median method, simple mode method, and weighted mode method results showed similar results.
CONCLUSION
This study offers evidence of sunburn history and increased risk of CM, and it shows that there might be common genetic basics regarding sunburns and CM susceptibility in Caucasian, European, or British ethnic groups.
背景
一些研究报告称晒伤与皮肤黑色素瘤（CM）风险正在增加，但尚未建立明确的因果联系。
方法
本研究采用两样本孟德尔随机化（MR）方法，利用大规模全基因组关联研究数据来阐明晒伤史与CM之间的关联及因果关系。
结果
逆方差加权法结果显示，晒伤可能与CM风险增加存在因果关联（p = 2.21×10，OR = 1.034，95%CI = 1.027 - 1.041）。MR-Egger回归、加权中位数法、简单模式法和加权模式法的结果显示出相似的结果。
结论
本研究为晒伤史与CM风险增加提供了证据，并表明在高加索人、欧洲人或英国种族群体中，晒伤与CM易感性可能存在共同的遗传基础。
Zotero 插件