Zarei-Ghanavati Siamak, Ostadimoghaddam Hadi, Najjaran Marzieh, Shoeibi Nasser, Ziaei Mohammed
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Curr Ophthalmol. 2024 Aug 10;35(4):381-386. doi: 10.4103/joco.joco_159_23. eCollection 2023 Oct-Dec.
To investigate peripapillary retinal nerve fiber layer (pRNFL) thickness changes in preterm children with or without retinopathy of prematurity (ROP) history compared to full-term children.
A retrospective comparative cohort study assessing pRNFL thickness was completed in children aged 4-8 years. Four groups of children were included ( = 30 each group): children with a history of ROP who were treated with intravitreal bevacizumab, children with ROP who received no treatment, and preterm children without ROP compared to age- and gender-matched full-term children.
A total of 120 eyes from 120 children were enrolled in this study. Both treated and regressed ROP children showed a significantly thinner pRNFL in the nasal quadrant compared to full-term children ( = 0.017 and = 0.008, respectively). The pRNFL in the superior quadrant of treated ROP children was thinner than the preterm and control groups ( = 0.015 and = 0.023, respectively), whereas the inferior quadrant of treated ROP children was thinner than the preterm group alone ( = 0.008). The pRNFL thickness in the temporal quadrant was comparable between groups ( = 0.129). The average spatial distribution profile of pRNFL thickness in treated ROP children was significantly thinner than in the preterm group ( = 0.041).
pRNFL thickness is significantly altered in children with a prior history of treated ROP with thinning of the nasal and superior quadrants compared to full-term children.
研究有或无早产儿视网膜病变（ROP）病史的早产儿与足月儿相比，其视乳头周围视网膜神经纤维层（pRNFL）厚度的变化。
对4至8岁儿童进行了一项评估pRNFL厚度的回顾性比较队列研究。纳入四组儿童（每组n = 30）：接受玻璃体内贝伐单抗治疗的ROP病史儿童、未接受治疗的ROP儿童、无ROP的早产儿，以及年龄和性别匹配的足月儿。
本研究共纳入120名儿童的120只眼。与足月儿相比，接受治疗和ROP消退的儿童在鼻侧象限的pRNFL均显著变薄（分别为P = 0.017和P = 0.008）。接受治疗的ROP儿童上象限的pRNFL比早产儿组和对照组更薄（分别为P = 0.015和P = 0.023），而接受治疗的ROP儿童下象限的pRNFL仅比早产儿组更薄（P = 0.008）。各组之间颞侧象限的pRNFL厚度相当（P = 0.129）。接受治疗的ROP儿童pRNFL厚度的平均空间分布轮廓比早产儿组显著更薄（P = 0.041）。
与足月儿相比，有治疗史的ROP儿童的pRNFL厚度有显著改变，鼻侧和上象限变薄。
