Retina Foundation of the Southwest, Dallas, Texas, USA.
Am J Ophthalmol. 2012 May;153(5):850-855.e1. doi: 10.1016/j.ajo.2011.10.028. Epub 2012 Feb 4.
To examine quantitatively characteristics of the peripapillary retinal nerve fiber layer (RNFL) in preterm children using Fourier-domain optical coherence tomography (FD-OCT).
Prospective cross-sectional study.
A 3-mm high-resolution FD-OCT peripapillary RNFL circular scan centered on the optic disc was obtained from right eyes of 25 preterm children (10.6 ± 3.7 years old, 8 preterm and 17 with regressed retinopathy of prematurity with normal-appearing posterior poles) and 54 full-term controls (9.8 ± 3.2 years old). Images were analyzed using Spectralis FD-OCT software to obtain average thickness measurements for 6 sectors (temporal superior, temporal, temporal inferior, nasal inferior, nasal, nasal superior), and the global average.
The RNFL global average for preterm children was 8% thinner than for full-term controls. In the preterm group, peripapillary RNFL thickness on the temporal side of the disc was 6% thicker than in full-term controls, while all other peripapillary RNFL sectors were 9% to 13% thinner. In the preterm group, temporal sector peripapillary RNFL thickness was correlated with gestational age (r = -0.47, P < .001), with foveal center total thickness (r = 0.48, P = .008, 1-tailed), and with visual acuity (r = 0.42; P = .026, 1-tailed).
The significantly thinner RNFL global average for preterm children suggests that prematurity is associated with subclinical optic nerve hypoplasia. Significant correlations between temporal sector RNFL thickness and both the foveal thickness and visual acuity suggest that the peripapillary RNFL is related to abnormalities in macular development as a result of preterm birth.
使用频域光学相干断层扫描（FD-OCT）定量分析早产儿视盘周围视网膜神经纤维层（RNFL）的特征。
前瞻性横断面研究。
对 25 名早产儿（10.6 ± 3.7 岁，8 名早产儿和 17 名早产儿视网膜病变消退但后极部正常）和 54 名足月产对照者（9.8 ± 3.2 岁）右眼进行 3mm 高分辨率 FD-OCT 视盘周围 RNFL 环形扫描。使用 Spectralis FD-OCT 软件分析图像，获得 6 个象限（颞上、颞、颞下、鼻下、鼻、鼻上）和全象限平均厚度测量值。
早产儿 RNFL 全象限平均厚度比足月产对照组薄 8%。在早产儿组，视盘颞侧的 RNFL 厚度比足月产对照组厚 6%，而其他所有视盘周围 RNFL 象限均薄 9%至 13%。在早产儿组，颞侧象限视盘周围 RNFL 厚度与胎龄呈负相关（r = -0.47，P <.001），与黄斑中心总厚度呈正相关（r = 0.48，P =.008，1 尾），与视力呈正相关（r = 0.42；P =.026，1 尾）。
早产儿 RNFL 全象限平均厚度明显变薄提示早产儿存在亚临床视神经发育不良。颞侧象限 RNFL 厚度与黄斑厚度和视力之间存在显著相关性，表明视盘周围 RNFL 与早产儿出生后黄斑发育异常有关。
