Alkhowailed Mohammad S
Department of Dermatology, College of Medicine, Qassim University, Buraidah, Qassim, Saudi Arabia.
Int J Health Sci (Qassim). 2024 Sep-Oct;18(5):59-61.
Angiokeratoma (AK) is an uncommon vascular cutaneous illness that is characterized by benign vascular ectasias of the papillary dermis combined with papillomatosis, acanthosis, and hyperkeratosis of the epidermis. It often presents as mainly asymptomatic. Here, we present a case of a 14-year-old Saudi male who presented to the dermatology clinic with red-to-black nodules of varying sizes on the palmar and dorsal surfaces of his left hand. Upon examination, the nodules were painless with no other constitutional symptoms. Laboratory investigations were unremarkable. A 4-mm skin punch biopsy showed dilated vascular channels at the papillary dermis and corneal layer with acanthotic epidermis with granulation tissue; these findings were suggestive of AKs of Mibelli. Timolol drops were prescribed twice daily for 1 month, and the patient was seen after a month with a 90% resolution of lesions. This case study describes an intriguing instance of eruptive AK of Mibelli that was treated with Timolol 0.5% drops and was localized unilaterally over the left hand in a youngster who had previously been in good health. To the best of our knowledge, no previously reported AK of Mibelli cases that responded to Timolol 0.5% drops.
血管角化瘤（AK）是一种罕见的皮肤血管疾病，其特征是乳头真皮层的良性血管扩张，同时伴有乳头瘤病、棘皮症和表皮角化过度。它通常主要表现为无症状。在此，我们报告一例14岁沙特男性病例，该患者因左手掌和手背出现大小不一的红黑色结节而就诊于皮肤科诊所。经检查，结节无痛，无其他全身症状。实验室检查无异常。4毫米皮肤穿刺活检显示乳头真皮层和角质层血管通道扩张，表皮棘皮症伴肉芽组织；这些发现提示为米贝利血管角化瘤。噻吗洛尔滴眼液每天使用两次，持续1个月，1个月后复查时，病变消退了90%。本病例研究描述了一例有趣的米贝利型爆发性血管角化瘤，该病例用0.5%噻吗洛尔滴眼液治疗，且单侧局限于一名此前健康的年轻人的左手。据我们所知，此前没有报道过米贝利血管角化瘤病例对0.5%噻吗洛尔滴眼液有反应。
