Li Xinzhi, Datta Aniruddha, Banerjee Shiladitya
Department of Physics, Carnegie Mellon University, Pittsburgh, PA, USA.
bioRxiv. 2024 Sep 6:2024.09.03.610990. doi: 10.1101/2024.09.03.610990.
Morphogenesis of developing tissues results from anisotropic growth, typically driven by polarized patterns of gene expression. Here we propose an alternative model of anisotropic growth driven by self-organized feedback between cell polarity, mechanical pressure, and cell division rates. Specifically, cell polarity alignment can induce spontaneous symmetry breaking in proliferation, resulting from the anisotropic distribution of mechanical pressure in the tissue. We show that proliferation anisotropy can be controlled by cellular elasticity, motility and contact inhibition, thereby elucidating the design principles for anisotropic morphogenesis.
发育中组织的形态发生源于各向异性生长，通常由基因表达的极化模式驱动。在此，我们提出一种由细胞极性、机械压力和细胞分裂速率之间的自组织反馈驱动的各向异性生长的替代模型。具体而言，细胞极性排列可诱导增殖过程中自发的对称性破缺，这是由组织中机械压力的各向异性分布导致的。我们表明，增殖各向异性可由细胞弹性、运动性和接触抑制控制，从而阐明各向异性形态发生的设计原则。
