Department of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, P. R. China.
Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, P. R. China.
J Mater Chem B. 2024 Oct 17;12(40):10134-10148. doi: 10.1039/d4tb00936c.
DNA computing is regarded as one of the most promising candidates for the next generation of molecular computers, utilizing DNA to execute Boolean logic operations. In recent decades, DNA computing has garnered widespread attention due to its powerful programmable and parallel computing capabilities, demonstrating significant potential in intelligent biological analysis. This review summarizes the latest advancements in DNA logic systems and their biomedical applications. Firstly, it introduces recent DNA logic systems based on various materials such as functional DNA sequences, nanomaterials, and three-dimensional DNA nanostructures. The material innovations driving DNA computing have been summarized, highlighting novel molecular reactions and analytical performance metrics like efficiency, sensitivity, and selectivity. Subsequently, it outlines the biomedical applications of DNA computing-based multi-biomarker analysis in cellular imaging, clinical diagnosis, and disease treatment. Additionally, it discusses the existing challenges and future research directions for the development of DNA computing.
DNA 计算被认为是下一代分子计算机最有前途的候选者之一，它利用 DNA 来执行布尔逻辑运算。在过去的几十年中，由于其强大的可编程和并行计算能力，DNA 计算引起了广泛的关注，在智能生物分析方面显示出了巨大的潜力。本综述总结了 DNA 逻辑系统及其在生物医学中的最新进展。首先，它介绍了基于各种材料的最新 DNA 逻辑系统，如功能 DNA 序列、纳米材料和三维 DNA 纳米结构。总结了推动 DNA 计算的材料创新，突出了新颖的分子反应和分析性能指标，如效率、灵敏度和选择性。随后，它概述了基于 DNA 计算的多生物标志物分析在细胞成像、临床诊断和疾病治疗中的生物医学应用。此外，还讨论了 DNA 计算发展所面临的挑战和未来的研究方向。
