帕博利珠单抗治疗HER2阳性胃癌 - Suppr

Pembrolizumab in HER2-Positive Gastric Cancer.

作者信息

Janjigian Yelena Y, Kawazoe Akihito, Bai Yuxian, Xu Jianming, Lonardi Sara, Metges Jean Phillipe, Yañez Patricio, Wyrwicz Lucjan S, Shen Lin, Ostapenko Yuriy, Bilici Mehmet, Chung Hyun Cheol, Shitara Kohei, Qin Shukui, Van Cutsem Eric, Tabernero Josep, Luo Suxia, Mahave Mauricio, Tang Yong, Lowery Maeve, Monteiro Maria M F, Xu Linzhi, Shih Chie-Schin, Sharan Kanu P, Bhagia Pooja, Rha Sun Young

机构信息

Memorial Sloan Kettering Cancer Center, New York, NY

National Cancer Hospital East, Kashiwa, Japan.

出版信息

N Engl J Med. 2024 Oct 10;391(14):1360-1362. doi: 10.1056/NEJMc2408121. Epub 2024 Sep 14.

DOI:10.1056/NEJMc2408121

PMID:39282917

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11620791/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33a1/11620791/22331e7361ef/nihms-2017218-f0001.jpg

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Pembrolizumab in HER2-Positive Gastric Cancer.帕博利珠单抗治疗HER2阳性胃癌

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本文引用的文献

Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial.帕博利珠单抗联合曲妥珠单抗和化疗治疗 HER2 阳性胃或胃食管交界腺癌：来自 3 期 KEYNOTE-811 随机安慰剂对照试验的中期分析。

Lancet. 2023 Dec 9;402(10418):2197-2208. doi: 10.1016/S0140-6736(23)02033-0. Epub 2023 Oct 20.

The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer.KEYNOTE-811 试验：双 PD-1 和 HER2 阻断在 HER2 阳性胃癌中的应用。

Nature. 2021 Dec;600(7890):727-730. doi: 10.1038/s41586-021-04161-3. Epub 2021 Dec 15.

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Pembrolizumab in HER2-Positive Gastric Cancer.

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