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腹腔镜超声引导下微波消融治疗犬肝细胞癌。

Laparoscopic ultrasound-guided microwave ablation of hepatocellular carcinoma in a dog.

机构信息

Department of Small Animal Clinical Sciences, Small Animal Teaching Hospital, University of Florida, Gainesville, Florida, USA.

Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA.

出版信息

Vet Surg. 2024 Nov;53(8):1495-1503. doi: 10.1111/vsu.14163. Epub 2024 Sep 16.

Abstract

OBJECTIVE

The aim of the study was to describe laparoscopic ultrasound (LUS) to guide microwave ablation (MWA) of hepatocellular carcinoma (HCC) in a dog.

ANIMALS

A 13-year-old female spayed Husky.

STUDY DESIGN

Case report.

METHODS

The dog was referred for laparoscopic MWA of a caudate lobe HCC measuring 2.7 cm × 1.9 cm× 2.3 cm. Laparoscopic ultrasound was used to guide percutaneous placement of a MWA probe within the caudate lobe mass. LUS was used to determine the tumor margins for placement of the probe within the medial and lateral aspects as well as the center of the mass. Additionally, LUS allowed visualization of vessels within the tumor so they could be avoided during probe placement.

RESULTS

Safe ablation was accomplished, and the dog recovered uneventfully with no complications. Follow-up computed tomography (CT) 3- and 12-months postoperatively revealed complete ablation of the caudate lobe mass. However, progressive increase in size of the right medial lobe mass occurred. Right medial liver lobectomy was performed 13 months after MWA, with a histopathologic diagnosis of HCC. The dog was euthanized 777 days post MWA and 1445 days post initial left lateral lobectomy for HCC.

CONCLUSION

Laparoscopic ultrasound was useful in guiding complete and safe MWA of an HCC in this dog. Laparoscopic ultrasound should be considered when performing laparoscopic MWA of liver lesions in dogs.

摘要

目的

本研究旨在描述腹腔镜超声(LUS)在犬肝细胞癌(HCC)微波消融(MWA)中的应用。

动物

一只 13 岁的雌性去势哈士奇犬。

研究设计

病例报告。

方法

这只犬因 2.7cm×1.9cm×2.3cm 的尾状叶 HCC 接受腹腔镜 MWA 治疗而被转诊。使用腹腔镜超声引导经皮将 MWA 探头置于尾状叶肿块内。LUS 用于确定探头在肿块的内侧和外侧以及中心的放置位置以确定肿瘤边缘。此外,LUS 还可以显示肿瘤内的血管,以便在探头放置时避开这些血管。

结果

安全地完成了消融,犬术后恢复顺利,无并发症。术后 3 个月和 12 个月的随访 CT 显示尾状叶肿块完全消融。然而,右侧内侧叶肿块的大小逐渐增大。MWA 后 13 个月进行了右侧内侧肝叶切除术,组织病理学诊断为 HCC。犬在 MWA 后 777 天和 HCC 左外侧叶切除术 1445 天后被安乐死。

结论

LUS 可用于指导犬 HCC 的完全和安全 MWA。在对犬进行腹腔镜 MWA 治疗肝脏病变时,应考虑使用腹腔镜超声。

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