Balzer K, Breuer N, Goebell H, Szy D, Quebe-Fehling E, Freundlieb O, Strötges M W
Dtsch Med Wochenschr. 1985 Sep 20;110(38):1452-7. doi: 10.1055/s-2008-1069027.
Faecal excretion of bile acids was investigated using 75Se-homotaurocholic acid (75SeHCAT) in a total of 75 patients: 9 with irritable colon, 58 with Crohn's disease and 8 with small-bowel resection due to various indications but without Crohn's disease. Bile acid malabsorption, taken as a pathological bile acid retention of less than 19%, was found present in 43 patients with diseased terminal ileum or with more than 20 cm resection of this organ, except in one case (12 cm). On the other hand a normal bile acid retention (21 to 27%) was found in 29 of 72 patients (including 9 patients with irritable colon) who showed either no radiologically detectable lesion of the ileum (n = 21) or changes involving an extension of up to 30 cm (inflammation or resection) in the terminal ileum (n = 8), with the exception of one case (50 cm). Three patients had a raised bile acid excretion contrary to clinical expectation: they had colitis Crohn without radiologically detectable involvement of the small intestine. Thus using the 75SeHCAT-retention test it seems possible to recognize functional disorders in diseased segments of the bowel before the appearance of radiologically detectable changes.
75SeHCAT is a suitable substance for investigations on the function of the lower small intestine.
使用75硒同型牛磺胆酸（75SeHCAT）对75例患者的胆汁酸粪便排泄情况进行了研究：9例患有肠易激综合征，58例患有克罗恩病，8例因各种原因进行小肠切除术但无克罗恩病。胆汁酸吸收不良被定义为病理性胆汁酸潴留低于19%，在43例患有病变末端回肠或该器官切除超过20厘米的患者中发现了胆汁酸吸收不良，但有1例（切除12厘米）除外。另一方面，在72例患者中的29例（包括9例肠易激综合征患者）中发现胆汁酸潴留正常（21%至27%），这些患者要么在影像学上未发现回肠病变（n = 21），要么末端回肠有长达30厘米的改变（炎症或切除）（n = 8），但有1例（切除50厘米）除外。有3例患者的胆汁酸排泄量升高，与临床预期相反：他们患有克罗恩结肠炎，但在影像学上未发现小肠受累。因此，使用75SeHCAT潴留试验似乎有可能在影像学上可检测到的变化出现之前识别出肠道病变节段的功能障碍。
75SeHCAT是一种适用于研究下小肠功能的物质。
