Dept of Oral Pathology, Microbiology and Forensic Odontology, King George's Medical University, Lucknow, 226003, UP, India.
Head Neck Pathol. 2024 Sep 16;18(1):83. doi: 10.1007/s12105-024-01655-0.
Giant cell-rich lesions are a diverse group of lesions that usually occur in bone and contain varying numbers of reactive osteoclastic-type multinucleate giant cells. These lesions present a challenge in pathologic diagnosis, often requiring a combination of clinical, radiographic, and histopathological assessments. The present retrospective observational study aims to provide a concise diagnostic criterion by combining all these parameters, which will aid in effective diagnosis and targeted treatment planning in the future.
Previously diagnosed cases of these lesions were taken from the archives and categorized as Central Giant Cell Granuloma (CGCG), CGCG with secondary Aneurysmal Bone Cyst (ABC), primary ABC, and Brown's Tumour. Their demographic characteristics along with clinical, radiological, and histological data were retrieved and compiled into the table. The data was then analyzed and classified into aggressive and non-aggressive CGCG according to the criteria set in the study.
10 reported cases were of isolated CGCG, 5 were CGCG with secondary ABC, 5 of Brown's tumor and 3 were that of conventional ABC. Out of these, the lesions showing extensive size along with an increased number of giant cells were categorized under aggressive CGCG, whereas those with less aggressive characteristics were categorized under non-aggressive CGCG. The aggressive category comprised 5 cases of isolated CGCG, 2 cases of CGCG with secondary ABC, 3 cases of primary ABC, and 5 of brown tumor, whilst the rest of the cases were categorized under non-aggressive CGCG.
Since all these share overlapping features, thereby this type of concise categorization is the dire need so that the lesions can have a precise diagnosis with treatment and follow-up intervals for aggressive lesions.
富含巨细胞的病变是一组多样化的病变，通常发生在骨骼中，含有不同数量的反应性破骨细胞样多核巨细胞。这些病变在病理诊断中具有挑战性，通常需要结合临床、影像学和组织病理学评估。本回顾性观察研究旨在通过结合所有这些参数提供一个简洁的诊断标准，这将有助于未来进行有效的诊断和针对性的治疗计划。
从档案中选取这些病变的已诊断病例，并将其分类为中央性巨细胞瘤（CGCG）、CGCG 伴继发性动脉瘤样骨囊肿（ABC）、原发性 ABC 和棕色瘤。他们的人口统计学特征以及临床、放射学和组织学数据被检索并编制成表格。然后对数据进行分析，并根据研究中设定的标准将其分类为侵袭性和非侵袭性 CGCG。
报告的 10 例为孤立性 CGCG，5 例为 CGCG 伴继发性 ABC，5 例为棕色瘤，3 例为常规 ABC。在这些病变中，表现为广泛大小和增加数量的巨细胞的病变被归类为侵袭性 CGCG，而那些具有较少侵袭性特征的病变被归类为非侵袭性 CGCG。侵袭性类别包括 5 例孤立性 CGCG、2 例 CGCG 伴继发性 ABC、3 例原发性 ABC 和 5 例棕色瘤，而其余病例则归类为非侵袭性 CGCG。
由于所有这些病变都具有重叠的特征，因此这种类型的简洁分类是迫切需要的，以便对病变进行精确诊断，并为侵袭性病变确定治疗和随访间隔。
