胰腺导管的发育及其对器官发生的贡献。
Development of the Pancreatic Ducts and Their Contribution to Organogenesis.
机构信息
Department of Biology, Indiana University-Indianapolis, Indianapolis, IN, USA.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
Adv Anat Embryol Cell Biol. 2024;239:31-55. doi: 10.1007/978-3-031-62232-8_2.
Abstract
The pancreas is a dual-function organ, with exocrine cells that aid in digestion and endocrine cells that regulate glucose homeostasis. These cell types share common progenitors and arise from the embryonic ducts. Early signaling events in the embryonic ducts shape the neonatal, adolescent, and adult exocrine and endocrine pancreas. This chapter discusses recent advances in the tools used to study the ducts and our current understanding of how ductal development contributes to pancreatic organogenesis.
摘要
胰腺是一个具有双重功能的器官，其中外分泌细胞有助于消化，内分泌细胞则调节葡萄糖的体内平衡。这些细胞类型具有共同的祖细胞，并且起源于胚胎导管。胚胎导管中的早期信号事件塑造了新生儿、青少年和成年期的外分泌和内分泌胰腺。本章讨论了用于研究导管的工具的最新进展，以及我们目前对导管发育如何促进胰腺发生的理解。
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