Scarpelli Francesca, Crispini Alessandra, Aiello Iolinda, Godbert Nicolas, Marchetti Fabio, Xhafa Sonila, De Filpo Giovanni, Baratta Mariafrancesca, Berardi Riccardo, Alfano Pasquale, Giorno Eugenia
MAT-InLAB, Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, 87036 Arcavacata di Rende, CS, Italy.
School of Science and Technology, Chemistry Section, University of Camerino, Via S. Agostino 1, 62032 Camerino, MC, Italy.
Dalton Trans. 2024 Oct 1;53(38):15992-16004. doi: 10.1039/d4dt02201g.
The effects exerted by new bioactive acylpyrazolonate Ag(I) derivatives of the general formula [Ag(QPy,CF3)(R-Im)] containing different substituents on the imidazole (R-Im) ancillary ligands and the natural plasticizer castor oil when both are added to the ethylcellulose (EC) biopolymer in the preparation of thin films as potential active food packaging materials are presented. The Ag(I) complexes [Ag(QPy,CF3)(Bn-Im)] and [Ag(QPy,CF3)(Bu-Im)], having benzyl and butyl substituents, whose single crystal molecular structures are reported, have proved to be highly compatible for efficient incorporation between the EC polymer and the hydrophobic plasticizer chains, giving rise, even at low concentrations, to homogeneous, robust and elastic films. The concomitant presence of these Ag(I) complexes and castor oil in the polymer EC matrix gives rise to thin films with improved antibacterial activity against () as a model of Gram-negative bacterial strains when compared to the non-plasticized ones, with very low Ag(I) migration in the three food simulants used (distilled water, ethanol 10% v/v and acetic acid 3% v/v) under two assay conditions (70 °C for 2 h and 40 °C for 10 days).
介绍了通式为[Ag(QPy,CF3)(R-Im)]的新型生物活性酰基吡唑啉酮银(I)衍生物，其咪唑（R-Im）辅助配体含有不同取代基，以及天然增塑剂蓖麻油，在制备潜在活性食品包装材料的薄膜时，将它们添加到乙基纤维素（EC）生物聚合物中的作用。已报道单晶分子结构的具有苄基和丁基取代基的银(I)配合物[Ag(QPy,CF3)(Bn-Im)]和[Ag(QPy,CF3)(Bu-Im)]，已被证明与EC聚合物和疏水性增塑剂链之间的有效掺入具有高度相容性，即使在低浓度下也能形成均匀、坚固且有弹性的薄膜。与未增塑的薄膜相比，这些银(I)配合物和蓖麻油同时存在于聚合物EC基质中，会产生对作为革兰氏阴性细菌菌株模型的（）具有改善抗菌活性的薄膜，在两种测定条件下（70°C 2小时和40°C 10天），在三种食品模拟物（蒸馏水、10% v/v乙醇和3% v/v乙酸）中银(I)的迁移率非常低。
