癫痫中的认知发展。癫痫活动与脑损伤的相对影响。

Cognitive development in epilepsy. The relative influence of epileptic activity and of brain damage.

作者信息

Niemann H, Boenick H E, Schmidt R C, Ettlinger G

出版信息

Eur Arch Psychiatry Neurol Sci. 1985;234(6):399-403. doi: 10.1007/BF00386058.

Abstract

A total of 37 children, aged between 12 and 18 years and resident in an epileptic colony, were assessed in several ways for the frequency of their epileptic discharging activity and for the extent of underlying brain pathology. In addition, the children were evaluated for their level of performance on various tests of cognitive and visuo-motor functions. The influence on test performance of the discharging activity and of the extent of pathology was then compared, taking other factors such as age at onset of the seizures, duration of the epileptic illness and level of medication into account as far as possible. Only two factors, namely certain indices of discharging activity and level of medication, were found to have significantly influenced particular aspects of cognitive performance; it was impossible to document an influence of brain pathology statistically.

摘要

共有37名年龄在12至18岁之间、居住在癫痫患者聚居地的儿童接受了多项评估，以了解其癫痫放电活动的频率以及潜在脑病理的程度。此外，还对这些儿童在各种认知和视觉运动功能测试中的表现水平进行了评估。然后，在尽可能考虑其他因素（如癫痫发作起始年龄、癫痫病程和用药水平）的情况下，比较了放电活动和病理程度对测试表现的影响。结果发现，只有两个因素，即放电活动的某些指标和用药水平，对认知表现的特定方面有显著影响；无法从统计学上证明脑病理的影响。