抗惊厥药血清水平：与认知功能损害的关系。
Anticonvulsant serum levels: relationship to impairments of cognitive functioning.
作者信息
Thompson P J, Trimble M R
出版信息
J Neurol Neurosurg Psychiatry. 1983 Mar;46(3):227-33. doi: 10.1136/jnnp.46.3.227.
Abstract
Twenty-eight patients with epilepsy were seen on two occasions at an interval of three months. On one session anticonvulsant serum levels were high and on the other session the serum levels were lower. On each of the two sessions patients performed a series of psychological tests and had a blood sample taken for the analysis of anticonvulsant serum concentrations. Seizure frequency in the previous three months was documented and several patients had an EEG recording made. Deficits in psychological test performance were found at high serum concentrations. Furthermore, lower serum level concentrations did not appear to be accompanied by worsened seizure control.
摘要
28名癫痫患者每隔三个月接受两次检查。一次检查时抗惊厥药血清水平较高，另一次检查时血清水平较低。在这两次检查中，患者均进行了一系列心理测试，并采集血样以分析抗惊厥药血清浓度。记录了前三个月的癫痫发作频率，部分患者还进行了脑电图记录。结果发现，血清浓度高时心理测试表现存在缺陷。此外，血清水平较低时癫痫控制情况似乎并未恶化。
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