Haas W, Kisielow P
Eur J Immunol. 1985 Aug;15(8):755-60. doi: 10.1002/eji.1830150803.
Interleukin 2 (IL2)-dependent cytolytic hybrids usually loose IL2 dependence and cytolytic activity concomittantly. Here we describe an exceptional IL2-independent variant which lost IL2 receptor but retained cytolytic activity. When the IL2-independent cytolytic hybrid cells were fused with IL2-dependent cytolytic clones which express IL2 receptors constitutively, IL2-dependent hybrids were obtained. This suggests that the expression of IL2 receptors can interfere with IL2-independent growth mechanisms.
白细胞介素2（IL2）依赖的溶细胞杂种通常会同时丧失对IL2的依赖性和溶细胞活性。在此，我们描述了一种特殊的不依赖IL2的变体，它失去了IL2受体但保留了溶细胞活性。当将不依赖IL2的溶细胞杂种细胞与组成性表达IL2受体的依赖IL2的溶细胞克隆融合时，获得了依赖IL2的杂种。这表明IL2受体的表达可以干扰不依赖IL2的生长机制。
