College of Pharmacy, Inner Mongolia Medical University, Inner Mongolia Jinshan Development Zone, Hohhot, Inner Mongolian Province 010110, China; School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
College of Pharmacy, Inner Mongolia Medical University, Inner Mongolia Jinshan Development Zone, Hohhot, Inner Mongolian Province 010110, China.
Drug Discov Today. 2024 Nov;29(11):104182. doi: 10.1016/j.drudis.2024.104182. Epub 2024 Sep 14.
Diabetes is a complex, multifactorial disease that is caused by a pathological combination of insulin resistance and pancreatic islet dysfunction. Polysaccharides are extensively dispersed in nature and have a very complicated structure with various biological properties. Natural polysaccharides have potentially extraordinary beneficial health effects on managing metabolic diseases such as diabetes, obesity and cardiovascular disease. Thus, a systematic review of the latest research into and possible regulatory mechanisms of natural polysaccharides for type 2 diabetes mellitus treatment is of great significance for a better understanding of their pharmaceutical value. We discuss the regulatory mechanisms of natural polysaccharides for the treatment of diabetes, and especially their role in reshaping dysfunctional gut microbiota. Natural polysaccharides could be developed as new and safe antidiabetic drugs, and detailed mechanistic studies could further clarify the molecular targets of polysaccharides in the treatment of diabetes.
糖尿病是一种复杂的、多因素的疾病，由胰岛素抵抗和胰岛功能障碍的病理组合引起。多糖广泛存在于自然界中，具有非常复杂的结构和多种生物特性。天然多糖对管理糖尿病、肥胖和心血管疾病等代谢疾病具有潜在的非凡健康益处。因此，系统地综述天然多糖治疗 2 型糖尿病的最新研究及其可能的调节机制，对于更好地理解其药用价值具有重要意义。我们讨论了天然多糖治疗糖尿病的调节机制，特别是它们在重塑功能失调的肠道微生物群中的作用。天然多糖可以开发为新型安全的抗糖尿病药物，详细的机制研究可以进一步阐明多糖在治疗糖尿病中的分子靶点。
