Zoucas E, Fäldt R, Ankerst J
Haemostasis. 1985;15(3):176-81. doi: 10.1159/000215141.
The effect of granulocytes on human platelet aggregation was investigated in vitro. Platelet function was assayed by photometric technique. Incubation of platelets with latex-stimulated granulocytes for 1 h at room temperature resulted in total inhibition of arachidonic acid-induced platelet aggregation. ADP-induced platelet aggregation was suppressed, lacked secondary wave and was pursued by swift disaggregation. Platelet aggregates induced by collagen dispersed faster under the influence of stimulated granulocytes. The present results indicate that granulocytes may play a role in the hemostatic mechanism in man.
在体外研究了粒细胞对人血小板聚集的影响。采用光度技术测定血小板功能。在室温下将血小板与乳胶刺激的粒细胞孵育1小时，导致花生四烯酸诱导的血小板聚集完全受到抑制。ADP诱导的血小板聚集受到抑制，缺乏二次波，并迅速解聚。在受刺激粒细胞的影响下，胶原蛋白诱导的血小板聚集体分散得更快。目前的结果表明，粒细胞可能在人类止血机制中发挥作用。
