多形核白细胞对人血小板活化的抑制作用。
Inhibition of human platelet activation by polymorphonuclear leukocytes.
作者信息
Schattner M A, Geffner J R, Isturiz M A, Lazzari M A
机构信息
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
出版信息
Br J Pharmacol. 1990 Oct;101(2):253-6. doi: 10.1111/j.1476-5381.1990.tb12696.x.
Abstract
- The effect of unstimulated human polymorphonuclear leukocytes (PMNs) on platelet activation was examined. 2. Human platelet aggregation and adenosine 5'-triphosphate (ATP) release induced by collagen (1-2 micrograms ml-1); thrombin (0.01-0.02 u ml-1) or arachidonic acid (AA) (0.1-0.2 mM) were markedly inhibited when conducted in the presence of unstimulated PMNs. 3. Platelet inhibition induced by PMNs was dependent on the number of PMNs and on the incubation time of the mixed cell suspension. 4. Platelet inhibition was not reversed in time when PMNs were depleted from the mixed-cell suspension. 5. PMN-mediated platelet-inhibition was not mediated by AA metabolites, oxygen reactive intermediates, nitric oxide or proteases. 6. The factor(s) accounting for the platelet inhibition mediated by PMNs are not yet characterized.
摘要
- 研究了未刺激的人多形核白细胞（PMN）对血小板活化的影响。2. 当在未刺激的PMN存在下进行时，由胶原蛋白（1 - 2微克/毫升）、凝血酶（0.01 - 0.02单位/毫升）或花生四烯酸（AA）（0.1 - 0.2毫摩尔）诱导的人血小板聚集和5'-三磷酸腺苷（ATP）释放受到显著抑制。3. PMN诱导的血小板抑制取决于PMN的数量和混合细胞悬液的孵育时间。4. 当从混合细胞悬液中去除PMN时，血小板抑制不会随时间逆转。5. PMN介导的血小板抑制不是由AA代谢产物、氧反应性中间体、一氧化氮或蛋白酶介导的。6. 导致PMN介导的血小板抑制的因素尚未明确。
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